Integrative analysis of the circRNA–miRNA regulatory network in atrial fibrillation

Abstract We aimed to investigate the circRNA–miRNA regulatory network in atrial fibrillation (AF) by using Cytoscape and HMDD v3.0. Finally, 120 differentially expressed circRNAs in peripheral blood monocytes of 4 AF patients were preliminarily screened by circRNA microarray. circRNA_4648, circRNA_4...

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Autores principales:	Zhong-bao Ruan, Fei Wang, Qiu-ping Yu, Ge-cai Chen, Li Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8dedcdfc5c6d42d3b731946f5af6618b
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spelling	oai:doaj.org-article:8dedcdfc5c6d42d3b731946f5af6618b2021-12-02T11:40:50ZIntegrative analysis of the circRNA–miRNA regulatory network in atrial fibrillation10.1038/s41598-020-77485-12045-2322https://doaj.org/article/8dedcdfc5c6d42d3b731946f5af6618b2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77485-1https://doaj.org/toc/2045-2322Abstract We aimed to investigate the circRNA–miRNA regulatory network in atrial fibrillation (AF) by using Cytoscape and HMDD v3.0. Finally, 120 differentially expressed circRNAs in peripheral blood monocytes of 4 AF patients were preliminarily screened by circRNA microarray. circRNA_4648, circRNA_4631, and circRNA_2875 were the first four circRNAs with the most binding nodes in the circRNA–miRNA network. The top three most frequent miRNAs for up-regulated circRNAs were hsa-miR-328 that interacted with 5 up-regulated circRNAs, hsa-miR-4685-5p with 4 up-regulated circRNAs, hsa-miR-3150a-3p, hsa-miR-4649-5p, hsa-miR-4783-3p, and hsa-miR-8073 with 3 up-regulated circRNAs,, while the top three most frequent miRNAs for down-regulated circRNAs were hsa-miR-328 that interacted with 14 down-regulated circRNAs, hsa-miR-4685-5p with 11 down-regulated circRNAs and hsa-miR-661 with 9 down-regulated circRNAs. According to HMDD v3.0, five up-regulated and eleven down-regulated circRNAs were found to interact with AF related miRNAs. These results indicated the possible regulatory network between circRNAs and miRNAs in the pathogenesis of AF.Zhong-bao RuanFei WangQiu-ping YuGe-cai ChenLi ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhong-bao Ruan Fei Wang Qiu-ping Yu Ge-cai Chen Li Zhu Integrative analysis of the circRNA–miRNA regulatory network in atrial fibrillation
description	Abstract We aimed to investigate the circRNA–miRNA regulatory network in atrial fibrillation (AF) by using Cytoscape and HMDD v3.0. Finally, 120 differentially expressed circRNAs in peripheral blood monocytes of 4 AF patients were preliminarily screened by circRNA microarray. circRNA_4648, circRNA_4631, and circRNA_2875 were the first four circRNAs with the most binding nodes in the circRNA–miRNA network. The top three most frequent miRNAs for up-regulated circRNAs were hsa-miR-328 that interacted with 5 up-regulated circRNAs, hsa-miR-4685-5p with 4 up-regulated circRNAs, hsa-miR-3150a-3p, hsa-miR-4649-5p, hsa-miR-4783-3p, and hsa-miR-8073 with 3 up-regulated circRNAs,, while the top three most frequent miRNAs for down-regulated circRNAs were hsa-miR-328 that interacted with 14 down-regulated circRNAs, hsa-miR-4685-5p with 11 down-regulated circRNAs and hsa-miR-661 with 9 down-regulated circRNAs. According to HMDD v3.0, five up-regulated and eleven down-regulated circRNAs were found to interact with AF related miRNAs. These results indicated the possible regulatory network between circRNAs and miRNAs in the pathogenesis of AF.
format	article
author	Zhong-bao Ruan Fei Wang Qiu-ping Yu Ge-cai Chen Li Zhu
author_facet	Zhong-bao Ruan Fei Wang Qiu-ping Yu Ge-cai Chen Li Zhu
author_sort	Zhong-bao Ruan
title	Integrative analysis of the circRNA–miRNA regulatory network in atrial fibrillation
title_short	Integrative analysis of the circRNA–miRNA regulatory network in atrial fibrillation
title_full	Integrative analysis of the circRNA–miRNA regulatory network in atrial fibrillation
title_fullStr	Integrative analysis of the circRNA–miRNA regulatory network in atrial fibrillation
title_full_unstemmed	Integrative analysis of the circRNA–miRNA regulatory network in atrial fibrillation
title_sort	integrative analysis of the circrna–mirna regulatory network in atrial fibrillation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8dedcdfc5c6d42d3b731946f5af6618b
work_keys_str_mv	AT zhongbaoruan integrativeanalysisofthecircrnamirnaregulatorynetworkinatrialfibrillation AT feiwang integrativeanalysisofthecircrnamirnaregulatorynetworkinatrialfibrillation AT qiupingyu integrativeanalysisofthecircrnamirnaregulatorynetworkinatrialfibrillation AT gecaichen integrativeanalysisofthecircrnamirnaregulatorynetworkinatrialfibrillation AT lizhu integrativeanalysisofthecircrnamirnaregulatorynetworkinatrialfibrillation
_version_	1718395529100001280

Integrative analysis of the circRNA–miRNA regulatory network in atrial fibrillation

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