Fine control of metal concentrations is necessary for cells to discern zinc from cobalt

Bacteria possess transcription factors whose DNA-binding activity is altered upon binding to specific metals, but the binding of metals is not specific in vitro. Here, Osman et al. show that tight regulation of buffered intracellular metal concentrations is a prerequisite for metal specificity.

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Detalles Bibliográficos
Autores principales:	Deenah Osman, Andrew W. Foster, Junjun Chen, Kotryna Svedaite, Jonathan W. Steed, Elena Lurie-Luke, Thomas G. Huggins, Nigel J. Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8dee7c1b410044ad893a2b322b638933
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spelling	oai:doaj.org-article:8dee7c1b410044ad893a2b322b6389332021-12-02T14:42:55ZFine control of metal concentrations is necessary for cells to discern zinc from cobalt10.1038/s41467-017-02085-z2041-1723https://doaj.org/article/8dee7c1b410044ad893a2b322b6389332017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02085-zhttps://doaj.org/toc/2041-1723Bacteria possess transcription factors whose DNA-binding activity is altered upon binding to specific metals, but the binding of metals is not specific in vitro. Here, Osman et al. show that tight regulation of buffered intracellular metal concentrations is a prerequisite for metal specificity.Deenah OsmanAndrew W. FosterJunjun ChenKotryna SvedaiteJonathan W. SteedElena Lurie-LukeThomas G. HugginsNigel J. RobinsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deenah Osman Andrew W. Foster Junjun Chen Kotryna Svedaite Jonathan W. Steed Elena Lurie-Luke Thomas G. Huggins Nigel J. Robinson Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
description	Bacteria possess transcription factors whose DNA-binding activity is altered upon binding to specific metals, but the binding of metals is not specific in vitro. Here, Osman et al. show that tight regulation of buffered intracellular metal concentrations is a prerequisite for metal specificity.
format	article
author	Deenah Osman Andrew W. Foster Junjun Chen Kotryna Svedaite Jonathan W. Steed Elena Lurie-Luke Thomas G. Huggins Nigel J. Robinson
author_facet	Deenah Osman Andrew W. Foster Junjun Chen Kotryna Svedaite Jonathan W. Steed Elena Lurie-Luke Thomas G. Huggins Nigel J. Robinson
author_sort	Deenah Osman
title	Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
title_short	Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
title_full	Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
title_fullStr	Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
title_full_unstemmed	Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
title_sort	fine control of metal concentrations is necessary for cells to discern zinc from cobalt
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8dee7c1b410044ad893a2b322b638933
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Fine control of metal concentrations is necessary for cells to discern zinc from cobalt

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