Fine control of metal concentrations is necessary for cells to discern zinc from cobalt

Bacteria possess transcription factors whose DNA-binding activity is altered upon binding to specific metals, but the binding of metals is not specific in vitro. Here, Osman et al. show that tight regulation of buffered intracellular metal concentrations is a prerequisite for metal specificity.

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Deenah Osman, Andrew W. Foster, Junjun Chen, Kotryna Svedaite, Jonathan W. Steed, Elena Lurie-Luke, Thomas G. Huggins, Nigel J. Robinson
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/8dee7c1b410044ad893a2b322b638933
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:8dee7c1b410044ad893a2b322b638933
record_format	dspace
spelling	oai:doaj.org-article:8dee7c1b410044ad893a2b322b6389332021-12-02T14:42:55ZFine control of metal concentrations is necessary for cells to discern zinc from cobalt10.1038/s41467-017-02085-z2041-1723https://doaj.org/article/8dee7c1b410044ad893a2b322b6389332017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02085-zhttps://doaj.org/toc/2041-1723Bacteria possess transcription factors whose DNA-binding activity is altered upon binding to specific metals, but the binding of metals is not specific in vitro. Here, Osman et al. show that tight regulation of buffered intracellular metal concentrations is a prerequisite for metal specificity.Deenah OsmanAndrew W. FosterJunjun ChenKotryna SvedaiteJonathan W. SteedElena Lurie-LukeThomas G. HugginsNigel J. RobinsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deenah Osman Andrew W. Foster Junjun Chen Kotryna Svedaite Jonathan W. Steed Elena Lurie-Luke Thomas G. Huggins Nigel J. Robinson Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
description	Bacteria possess transcription factors whose DNA-binding activity is altered upon binding to specific metals, but the binding of metals is not specific in vitro. Here, Osman et al. show that tight regulation of buffered intracellular metal concentrations is a prerequisite for metal specificity.
format	article
author	Deenah Osman Andrew W. Foster Junjun Chen Kotryna Svedaite Jonathan W. Steed Elena Lurie-Luke Thomas G. Huggins Nigel J. Robinson
author_facet	Deenah Osman Andrew W. Foster Junjun Chen Kotryna Svedaite Jonathan W. Steed Elena Lurie-Luke Thomas G. Huggins Nigel J. Robinson
author_sort	Deenah Osman
title	Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
title_short	Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
title_full	Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
title_fullStr	Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
title_full_unstemmed	Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
title_sort	fine control of metal concentrations is necessary for cells to discern zinc from cobalt
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8dee7c1b410044ad893a2b322b638933
work_keys_str_mv	AT deenahosman finecontrolofmetalconcentrationsisnecessaryforcellstodiscernzincfromcobalt AT andrewwfoster finecontrolofmetalconcentrationsisnecessaryforcellstodiscernzincfromcobalt AT junjunchen finecontrolofmetalconcentrationsisnecessaryforcellstodiscernzincfromcobalt AT kotrynasvedaite finecontrolofmetalconcentrationsisnecessaryforcellstodiscernzincfromcobalt AT jonathanwsteed finecontrolofmetalconcentrationsisnecessaryforcellstodiscernzincfromcobalt AT elenalurieluke finecontrolofmetalconcentrationsisnecessaryforcellstodiscernzincfromcobalt AT thomasghuggins finecontrolofmetalconcentrationsisnecessaryforcellstodiscernzincfromcobalt AT nigeljrobinson finecontrolofmetalconcentrationsisnecessaryforcellstodiscernzincfromcobalt
_version_	1718389582105411584

Fine control of metal concentrations is necessary for cells to discern zinc from cobalt

Documents similaires