Gut Microbial Succession Follows Acute Secretory Diarrhea in Humans

ABSTRACT Disability after childhood diarrhea is an important burden on global productivity. Recent studies suggest that gut bacterial communities influence how humans recover from infectious diarrhea, but we still lack extensive data and mechanistic hypotheses for how these bacterial communities res...

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Autores principales:	Lawrence A. David, Ana Weil, Edward T. Ryan, Stephen B. Calderwood, Jason B. Harris, Fahima Chowdhury, Yasmin Begum, Firdausi Qadri, Regina C. LaRocque, Peter J. Turnbaugh
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2015
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/8df31ab956044052ba461764ca213e14
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spelling	oai:doaj.org-article:8df31ab956044052ba461764ca213e142021-11-15T15:49:02ZGut Microbial Succession Follows Acute Secretory Diarrhea in Humans10.1128/mBio.00381-152150-7511https://doaj.org/article/8df31ab956044052ba461764ca213e142015-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00381-15https://doaj.org/toc/2150-7511ABSTRACT Disability after childhood diarrhea is an important burden on global productivity. Recent studies suggest that gut bacterial communities influence how humans recover from infectious diarrhea, but we still lack extensive data and mechanistic hypotheses for how these bacterial communities respond to diarrheal disease and its treatment. Here, we report that after Vibrio cholerae infection, the human gut microbiota undergoes an orderly and reproducible succession that features transient reversals in relative levels of enteric Bacteroides and Prevotella. Elements of this succession may be a common feature in microbiota recovery from acute secretory diarrhea, as we observed similar successional dynamics after enterotoxigenic Escherichia coli (ETEC) infection. Our metagenomic analyses suggest that multiple mechanisms drive microbial succession after cholera, including bacterial dispersal properties, changing enteric oxygen and carbohydrate levels, and phage dynamics. Thus, gut microbiota recovery after cholera may be predictable at the level of community structure but is driven by a complex set of temporally varying ecological processes. Our findings suggest opportunities for diagnostics and therapies targeting the gut microbiota in humans recovering from infectious diarrhea. IMPORTANCE Disability after diarrhea is a major burden on public health in the developing world. Gut bacteria may affect this recovery, but it remains incompletely understood how resident microbes in the digestive tract respond to diarrheal illness. Here, we observed an orderly and reproducible succession of gut bacterial groups after cholera in humans. Genomic analyses associated the succession with bacterial dispersal in food, an altered microbial environment, and changing phage levels. Our findings suggest that it may one day be feasible to manage resident bacterial populations in the gut after infectious diarrhea.Lawrence A. DavidAna WeilEdward T. RyanStephen B. CalderwoodJason B. HarrisFahima ChowdhuryYasmin BegumFirdausi QadriRegina C. LaRocquePeter J. TurnbaughAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 6, Iss 3 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Lawrence A. David Ana Weil Edward T. Ryan Stephen B. Calderwood Jason B. Harris Fahima Chowdhury Yasmin Begum Firdausi Qadri Regina C. LaRocque Peter J. Turnbaugh Gut Microbial Succession Follows Acute Secretory Diarrhea in Humans
description	ABSTRACT Disability after childhood diarrhea is an important burden on global productivity. Recent studies suggest that gut bacterial communities influence how humans recover from infectious diarrhea, but we still lack extensive data and mechanistic hypotheses for how these bacterial communities respond to diarrheal disease and its treatment. Here, we report that after Vibrio cholerae infection, the human gut microbiota undergoes an orderly and reproducible succession that features transient reversals in relative levels of enteric Bacteroides and Prevotella. Elements of this succession may be a common feature in microbiota recovery from acute secretory diarrhea, as we observed similar successional dynamics after enterotoxigenic Escherichia coli (ETEC) infection. Our metagenomic analyses suggest that multiple mechanisms drive microbial succession after cholera, including bacterial dispersal properties, changing enteric oxygen and carbohydrate levels, and phage dynamics. Thus, gut microbiota recovery after cholera may be predictable at the level of community structure but is driven by a complex set of temporally varying ecological processes. Our findings suggest opportunities for diagnostics and therapies targeting the gut microbiota in humans recovering from infectious diarrhea. IMPORTANCE Disability after diarrhea is a major burden on public health in the developing world. Gut bacteria may affect this recovery, but it remains incompletely understood how resident microbes in the digestive tract respond to diarrheal illness. Here, we observed an orderly and reproducible succession of gut bacterial groups after cholera in humans. Genomic analyses associated the succession with bacterial dispersal in food, an altered microbial environment, and changing phage levels. Our findings suggest that it may one day be feasible to manage resident bacterial populations in the gut after infectious diarrhea.
format	article
author	Lawrence A. David Ana Weil Edward T. Ryan Stephen B. Calderwood Jason B. Harris Fahima Chowdhury Yasmin Begum Firdausi Qadri Regina C. LaRocque Peter J. Turnbaugh
author_facet	Lawrence A. David Ana Weil Edward T. Ryan Stephen B. Calderwood Jason B. Harris Fahima Chowdhury Yasmin Begum Firdausi Qadri Regina C. LaRocque Peter J. Turnbaugh
author_sort	Lawrence A. David
title	Gut Microbial Succession Follows Acute Secretory Diarrhea in Humans
title_short	Gut Microbial Succession Follows Acute Secretory Diarrhea in Humans
title_full	Gut Microbial Succession Follows Acute Secretory Diarrhea in Humans
title_fullStr	Gut Microbial Succession Follows Acute Secretory Diarrhea in Humans
title_full_unstemmed	Gut Microbial Succession Follows Acute Secretory Diarrhea in Humans
title_sort	gut microbial succession follows acute secretory diarrhea in humans
publisher	American Society for Microbiology
publishDate	2015
url	https://doaj.org/article/8df31ab956044052ba461764ca213e14
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Gut Microbial Succession Follows Acute Secretory Diarrhea in Humans

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