Associations between the gut microbiome and fatigue in cancer patients

Abstract Fatigue is the most prevalent symptom of cancer and its treatments. Changes in the intestinal microbiome have been identified in chronic fatigue syndrome and other neuropsychiatric disorders, and cancer patients. However, the association between intestinal microbiome and fatigue in patients...

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Autores principales:	Joud Hajjar, Tito Mendoza, Liangliang Zhang, Siqing Fu, Sarina A. Piha-Paul, David S. Hong, Filip Janku, Daniel D. Karp, Alexej Ballhausen, Jing Gong, Abdulrazzak Zarifa, Christine B. Peterson, Funda Meric-Bernstam, Robert Jenq, Aung Naing
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8df7e07740964adfadc98678f9ef6a50
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spelling	oai:doaj.org-article:8df7e07740964adfadc98678f9ef6a502021-12-02T13:31:11ZAssociations between the gut microbiome and fatigue in cancer patients10.1038/s41598-021-84783-92045-2322https://doaj.org/article/8df7e07740964adfadc98678f9ef6a502021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84783-9https://doaj.org/toc/2045-2322Abstract Fatigue is the most prevalent symptom of cancer and its treatments. Changes in the intestinal microbiome have been identified in chronic fatigue syndrome and other neuropsychiatric disorders, and cancer patients. However, the association between intestinal microbiome and fatigue in patients with advanced cancers has not been evaluated. Understanding the connection between intestinal microbiome and fatigue will provide interventional and therapeutic opportunities to manipulate the microbiome to improve fatigue and other patients’ reported outcomes. In this project, we aimed to identify associations between microbiome composition and fatigue in advanced cancer patients. In this cross-sectional observational study at a tertiary cancer care center, we included 88 patients with advanced, metastatic, unresectable cancers who were in a washout period from chemotherapy. We measured fatigue using the MD Anderson Symptom Inventory—Immunotherapy fatigue score, and used 16srRNA to analyze intestinal microbiome. Using correlation analysis we found that Eubacterium hallii was negatively associated with fatigue severity scores (r = − 0.30, p = 0.005), whereas Cosenzaea was positively associated with fatigue scores (r = 0.33, p = 0.0002). We identified microbial species that exhibit distinct composition between high-fatigued and low-fatigued cancer patients. Further studies are warranted to investigate whether modulating the microbiome reduces cancer patients’ fatigue severity and improves their quality of life.Joud HajjarTito MendozaLiangliang ZhangSiqing FuSarina A. Piha-PaulDavid S. HongFilip JankuDaniel D. KarpAlexej BallhausenJing GongAbdulrazzak ZarifaChristine B. PetersonFunda Meric-BernstamRobert JenqAung NaingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joud Hajjar Tito Mendoza Liangliang Zhang Siqing Fu Sarina A. Piha-Paul David S. Hong Filip Janku Daniel D. Karp Alexej Ballhausen Jing Gong Abdulrazzak Zarifa Christine B. Peterson Funda Meric-Bernstam Robert Jenq Aung Naing Associations between the gut microbiome and fatigue in cancer patients
description	Abstract Fatigue is the most prevalent symptom of cancer and its treatments. Changes in the intestinal microbiome have been identified in chronic fatigue syndrome and other neuropsychiatric disorders, and cancer patients. However, the association between intestinal microbiome and fatigue in patients with advanced cancers has not been evaluated. Understanding the connection between intestinal microbiome and fatigue will provide interventional and therapeutic opportunities to manipulate the microbiome to improve fatigue and other patients’ reported outcomes. In this project, we aimed to identify associations between microbiome composition and fatigue in advanced cancer patients. In this cross-sectional observational study at a tertiary cancer care center, we included 88 patients with advanced, metastatic, unresectable cancers who were in a washout period from chemotherapy. We measured fatigue using the MD Anderson Symptom Inventory—Immunotherapy fatigue score, and used 16srRNA to analyze intestinal microbiome. Using correlation analysis we found that Eubacterium hallii was negatively associated with fatigue severity scores (r = − 0.30, p = 0.005), whereas Cosenzaea was positively associated with fatigue scores (r = 0.33, p = 0.0002). We identified microbial species that exhibit distinct composition between high-fatigued and low-fatigued cancer patients. Further studies are warranted to investigate whether modulating the microbiome reduces cancer patients’ fatigue severity and improves their quality of life.
format	article
author	Joud Hajjar Tito Mendoza Liangliang Zhang Siqing Fu Sarina A. Piha-Paul David S. Hong Filip Janku Daniel D. Karp Alexej Ballhausen Jing Gong Abdulrazzak Zarifa Christine B. Peterson Funda Meric-Bernstam Robert Jenq Aung Naing
author_facet	Joud Hajjar Tito Mendoza Liangliang Zhang Siqing Fu Sarina A. Piha-Paul David S. Hong Filip Janku Daniel D. Karp Alexej Ballhausen Jing Gong Abdulrazzak Zarifa Christine B. Peterson Funda Meric-Bernstam Robert Jenq Aung Naing
author_sort	Joud Hajjar
title	Associations between the gut microbiome and fatigue in cancer patients
title_short	Associations between the gut microbiome and fatigue in cancer patients
title_full	Associations between the gut microbiome and fatigue in cancer patients
title_fullStr	Associations between the gut microbiome and fatigue in cancer patients
title_full_unstemmed	Associations between the gut microbiome and fatigue in cancer patients
title_sort	associations between the gut microbiome and fatigue in cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8df7e07740964adfadc98678f9ef6a50
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Associations between the gut microbiome and fatigue in cancer patients

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