Chalcone-Derived Nrf2 Activator Protects Cognitive Function via Maintaining Neuronal Redox Status
NF-E2-related factor 2 (Nrf2), the key transcription regulator of phase II enzymes, has been considered beneficial for neuronal protection. We previously designed a novel chalcone analog, 1-(2,3,4-trimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-acrylketone (Tak), that could specifically activate Nrf2 i...
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Auteurs principaux: | Yuting Cui, Yue Xiong, Hua Li, Mengqi Zeng, Yan Wang, Yuan Li, Xuan Zou, Weiqiang Lv, Jing Gao, Ruijun Cao, Lingjie Meng, Jiangang Long, Jiankang Liu, Zhihui Feng |
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Format: | article |
Langue: | EN |
Publié: |
MDPI AG
2021
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Accès en ligne: | https://doaj.org/article/8df8bef1c35f4d4a98dffc370f1fddb5 |
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