Efficacy and Safety of Various Treatments for Proliferative Diabetic Retinopathy: A Systematic Review and Network Meta-Analysis

Diabetic retinopathy is the main cause of visual impairment and blindness. The proliferative diabetic retinopathy at the severe stage of diabetic retinopathy is more harmful to vision and even leads to total blindness. To evaluate the visual acuity, central retinal thickness, and adverse reactions o...

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Autores principales:	Bo Zhang, Zhulin Zhou, Bingjie Zhang, Dan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	proliferative diabetic retinopathy systematic review network meta-analysis laser photocoagulation anti-VEGF (vascular endothelial growth factor) Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8dfe46a2b6fb425a8d09f1fd27940054
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spelling	oai:doaj.org-article:8dfe46a2b6fb425a8d09f1fd279400542021-11-09T05:57:16ZEfficacy and Safety of Various Treatments for Proliferative Diabetic Retinopathy: A Systematic Review and Network Meta-Analysis1663-981210.3389/fphar.2021.709501https://doaj.org/article/8dfe46a2b6fb425a8d09f1fd279400542021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.709501/fullhttps://doaj.org/toc/1663-9812Diabetic retinopathy is the main cause of visual impairment and blindness. The proliferative diabetic retinopathy at the severe stage of diabetic retinopathy is more harmful to vision and even leads to total blindness. To evaluate the visual acuity, central retinal thickness, and adverse reactions of various treatments for proliferative diabetic retinopathy through a systematic network meta-analysis. The relevant research published in English or Chinese from January 1, 2011, to February 1, 2021, was systematically searched by using PubMed, science network, EMBASE, MEDLINE, Cochrane Library, China National Knowledge Infrastructure, Wanfang, and other electronic databases. A total of 15 studies were selected, including 3,222 eyes of PDR patients. Our results show that in terms of visual score improvement, ranibizumab alone (69.90%) and laser + ranibizumab (67.90%) are the best. However, if the groups were grouped again according to the dose and times of ranibizumab injection, the results showed that 0.5 mg ranibizumab injection per month (58.0%) had the best effect on vision improvement. For the change of central retinal thickness, the thickness decreased the most after the laser combined with ranibizumab (96.5%). After the same subgroup analysis, the results were further refined into the best effect of laser combined with 0.3 mg ranibizumab per quarter (72.7%). In addition, our analysis of complications also showed that the overall incidence of adverse reactions of PRP (11.1 ± 12.4, %) was greater than that of ranibizumab (10.6 ± 13.0, %). However, more high-quality randomized controlled trials with longer follow-up using standard methods are still needed to verify the correlation.Bo ZhangZhulin ZhouBingjie ZhangDan WangFrontiers Media S.A.articleproliferative diabetic retinopathysystematic reviewnetwork meta-analysislaser photocoagulationanti-VEGF (vascular endothelial growth factor)Therapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	proliferative diabetic retinopathy systematic review network meta-analysis laser photocoagulation anti-VEGF (vascular endothelial growth factor) Therapeutics. Pharmacology RM1-950
spellingShingle	proliferative diabetic retinopathy systematic review network meta-analysis laser photocoagulation anti-VEGF (vascular endothelial growth factor) Therapeutics. Pharmacology RM1-950 Bo Zhang Zhulin Zhou Bingjie Zhang Dan Wang Efficacy and Safety of Various Treatments for Proliferative Diabetic Retinopathy: A Systematic Review and Network Meta-Analysis
description	Diabetic retinopathy is the main cause of visual impairment and blindness. The proliferative diabetic retinopathy at the severe stage of diabetic retinopathy is more harmful to vision and even leads to total blindness. To evaluate the visual acuity, central retinal thickness, and adverse reactions of various treatments for proliferative diabetic retinopathy through a systematic network meta-analysis. The relevant research published in English or Chinese from January 1, 2011, to February 1, 2021, was systematically searched by using PubMed, science network, EMBASE, MEDLINE, Cochrane Library, China National Knowledge Infrastructure, Wanfang, and other electronic databases. A total of 15 studies were selected, including 3,222 eyes of PDR patients. Our results show that in terms of visual score improvement, ranibizumab alone (69.90%) and laser + ranibizumab (67.90%) are the best. However, if the groups were grouped again according to the dose and times of ranibizumab injection, the results showed that 0.5 mg ranibizumab injection per month (58.0%) had the best effect on vision improvement. For the change of central retinal thickness, the thickness decreased the most after the laser combined with ranibizumab (96.5%). After the same subgroup analysis, the results were further refined into the best effect of laser combined with 0.3 mg ranibizumab per quarter (72.7%). In addition, our analysis of complications also showed that the overall incidence of adverse reactions of PRP (11.1 ± 12.4, %) was greater than that of ranibizumab (10.6 ± 13.0, %). However, more high-quality randomized controlled trials with longer follow-up using standard methods are still needed to verify the correlation.
format	article
author	Bo Zhang Zhulin Zhou Bingjie Zhang Dan Wang
author_facet	Bo Zhang Zhulin Zhou Bingjie Zhang Dan Wang
author_sort	Bo Zhang
title	Efficacy and Safety of Various Treatments for Proliferative Diabetic Retinopathy: A Systematic Review and Network Meta-Analysis
title_short	Efficacy and Safety of Various Treatments for Proliferative Diabetic Retinopathy: A Systematic Review and Network Meta-Analysis
title_full	Efficacy and Safety of Various Treatments for Proliferative Diabetic Retinopathy: A Systematic Review and Network Meta-Analysis
title_fullStr	Efficacy and Safety of Various Treatments for Proliferative Diabetic Retinopathy: A Systematic Review and Network Meta-Analysis
title_full_unstemmed	Efficacy and Safety of Various Treatments for Proliferative Diabetic Retinopathy: A Systematic Review and Network Meta-Analysis
title_sort	efficacy and safety of various treatments for proliferative diabetic retinopathy: a systematic review and network meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8dfe46a2b6fb425a8d09f1fd27940054
work_keys_str_mv	AT bozhang efficacyandsafetyofvarioustreatmentsforproliferativediabeticretinopathyasystematicreviewandnetworkmetaanalysis AT zhulinzhou efficacyandsafetyofvarioustreatmentsforproliferativediabeticretinopathyasystematicreviewandnetworkmetaanalysis AT bingjiezhang efficacyandsafetyofvarioustreatmentsforproliferativediabeticretinopathyasystematicreviewandnetworkmetaanalysis AT danwang efficacyandsafetyofvarioustreatmentsforproliferativediabeticretinopathyasystematicreviewandnetworkmetaanalysis
_version_	1718441314087862272

Efficacy and Safety of Various Treatments for Proliferative Diabetic Retinopathy: A Systematic Review and Network Meta-Analysis

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