Preparation, characterization and pharmacokinetics of cyadox nanosuspension

Abstract An increase in number of newly developed synthetic drugs displays bioavailability constraints because of poor water solubility. Nanosuspensions formulation may help to overwhelm these problems by increasing dissolution velocity and saturation solubility. In the present study, cyadox (Cyx) n...

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Autores principales:	Adeel Sattar, Dongmei Chen, Lishun Jiang, Yuanhu Pan, Yanfei Tao, Lingli Huang, Zhenli Liu, Shuyu Xie, Zonghui Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8dfee1f051bd47a78c45c6d972045875
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spelling	oai:doaj.org-article:8dfee1f051bd47a78c45c6d9720458752021-12-02T16:06:44ZPreparation, characterization and pharmacokinetics of cyadox nanosuspension10.1038/s41598-017-02523-42045-2322https://doaj.org/article/8dfee1f051bd47a78c45c6d9720458752017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02523-4https://doaj.org/toc/2045-2322Abstract An increase in number of newly developed synthetic drugs displays bioavailability constraints because of poor water solubility. Nanosuspensions formulation may help to overwhelm these problems by increasing dissolution velocity and saturation solubility. In the present study, cyadox (Cyx) nanosuspension was successfully prepared by recrystallization based on acid–base neutralization combined with high pressure homogenization method using Polyvinylpyrrolidone K30 (PVP) as stabilizer. The nanosuspension had uniform particle distribution, excellent sedimentation rate and redispersibility. The nanosuspension significantly improved the solubility, dissolution and bioavailability. The saturation solubility of Cyx nanocrystal was higher than that of bulk Cyx and released the total drug in very short time. Further, pharmacokinetics of Cyx nanosuspension and normal suspension following oral administration was investigated in beagle dogs. Nanosuspension improved the bioavailability of Cyx which could be beneficial for intestinal bacterial infection in animals. Maximum concentration and area under concentration time curve were increased with particles size reduction which might give rise to pronounce fluctuations in plasma concentration and more intensified antibacterial effects. The terminal half-life and mean resident time of Cyx nanosuspension had also increased compared to normal Cyx suspension. In conclusion, nanosuspensions may be a suitable delivery approach to increase the bioavailability of poorly soluble drugs.Adeel SattarDongmei ChenLishun JiangYuanhu PanYanfei TaoLingli HuangZhenli LiuShuyu XieZonghui YuanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adeel Sattar Dongmei Chen Lishun Jiang Yuanhu Pan Yanfei Tao Lingli Huang Zhenli Liu Shuyu Xie Zonghui Yuan Preparation, characterization and pharmacokinetics of cyadox nanosuspension
description	Abstract An increase in number of newly developed synthetic drugs displays bioavailability constraints because of poor water solubility. Nanosuspensions formulation may help to overwhelm these problems by increasing dissolution velocity and saturation solubility. In the present study, cyadox (Cyx) nanosuspension was successfully prepared by recrystallization based on acid–base neutralization combined with high pressure homogenization method using Polyvinylpyrrolidone K30 (PVP) as stabilizer. The nanosuspension had uniform particle distribution, excellent sedimentation rate and redispersibility. The nanosuspension significantly improved the solubility, dissolution and bioavailability. The saturation solubility of Cyx nanocrystal was higher than that of bulk Cyx and released the total drug in very short time. Further, pharmacokinetics of Cyx nanosuspension and normal suspension following oral administration was investigated in beagle dogs. Nanosuspension improved the bioavailability of Cyx which could be beneficial for intestinal bacterial infection in animals. Maximum concentration and area under concentration time curve were increased with particles size reduction which might give rise to pronounce fluctuations in plasma concentration and more intensified antibacterial effects. The terminal half-life and mean resident time of Cyx nanosuspension had also increased compared to normal Cyx suspension. In conclusion, nanosuspensions may be a suitable delivery approach to increase the bioavailability of poorly soluble drugs.
format	article
author	Adeel Sattar Dongmei Chen Lishun Jiang Yuanhu Pan Yanfei Tao Lingli Huang Zhenli Liu Shuyu Xie Zonghui Yuan
author_facet	Adeel Sattar Dongmei Chen Lishun Jiang Yuanhu Pan Yanfei Tao Lingli Huang Zhenli Liu Shuyu Xie Zonghui Yuan
author_sort	Adeel Sattar
title	Preparation, characterization and pharmacokinetics of cyadox nanosuspension
title_short	Preparation, characterization and pharmacokinetics of cyadox nanosuspension
title_full	Preparation, characterization and pharmacokinetics of cyadox nanosuspension
title_fullStr	Preparation, characterization and pharmacokinetics of cyadox nanosuspension
title_full_unstemmed	Preparation, characterization and pharmacokinetics of cyadox nanosuspension
title_sort	preparation, characterization and pharmacokinetics of cyadox nanosuspension
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8dfee1f051bd47a78c45c6d972045875
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Preparation, characterization and pharmacokinetics of cyadox nanosuspension

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