Clinical Persistence of <named-content content-type="genus-species">Chlamydia trachomatis</named-content> Sexually Transmitted Strains Involves Novel Mutations in the Functional αββα Tetramer of the Tryptophan Synthase Operon

Clinical Persistence of <named-content content-type="genus-species">Chlamydia trachomatis</named-content> Sexually Transmitted Strains Involves Novel Mutations in the Functional αββα Tetramer of the Tryptophan Synthase Operon

ABSTRACT Clinical persistence of Chlamydia trachomatis (Ct) sexually transmitted infections (STIs) is a major public health concern. In vitro persistence is known to develop through interferon gamma (IFN-γ) induction of indoleamine 2,3-dioxygenase (IDO), which catabolizes tryptophan, an essential am...

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Autores principales: Naraporn Somboonna, Noa Ziklo, Thomas E. Ferrin, Jung Hyuk Suh, Deborah Dean
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
Chlamydia trachomatis
indole
interferon gamma
sexually transmitted infections
trpA
tryptophan synthesis
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/8e023c33226040bcb3d0601379d86a27
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