Adiponectin-expressing Treg facilitate T lymphocyte development in thymic nurse cell complexes

Adiponectin-expressing Treg facilitate T lymphocyte development in thymic nurse cell complexes

Zhang, Cao et al. show that adiponectin is important for the selection and development of T lymphocytes within thymic nurse cell complexes. They find that regulatory T-cells (Treg) expressing adiponectin improve glucose metabolism in obese mice and promote central tolerance to inhibit mammary tumor...

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Autores principales: Yiwei Zhang, Handi Cao, Jie Chen, Yuanxin Li, Aimin Xu, Yu Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/8e0492b178fa4e19bcae97039bdba8a0
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spelling oai:doaj.org-article:8e0492b178fa4e19bcae97039bdba8a02021-12-02T13:17:48ZAdiponectin-expressing Treg facilitate T lymphocyte development in thymic nurse cell complexes10.1038/s42003-021-01877-w2399-3642https://doaj.org/article/8e0492b178fa4e19bcae97039bdba8a02021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01877-whttps://doaj.org/toc/2399-3642Zhang, Cao et al. show that adiponectin is important for the selection and development of T lymphocytes within thymic nurse cell complexes. They find that regulatory T-cells (Treg) expressing adiponectin improve glucose metabolism in obese mice and promote central tolerance to inhibit mammary tumor growth. This study suggests adiponectin-expressing Treg as a promising therapeutic agent against obesity-related metabolic and cancer diseases.Yiwei ZhangHandi CaoJie ChenYuanxin LiAimin XuYu WangNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Yiwei Zhang
Handi Cao
Jie Chen
Yuanxin Li
Aimin Xu
Yu Wang
Adiponectin-expressing Treg facilitate T lymphocyte development in thymic nurse cell complexes
description Zhang, Cao et al. show that adiponectin is important for the selection and development of T lymphocytes within thymic nurse cell complexes. They find that regulatory T-cells (Treg) expressing adiponectin improve glucose metabolism in obese mice and promote central tolerance to inhibit mammary tumor growth. This study suggests adiponectin-expressing Treg as a promising therapeutic agent against obesity-related metabolic and cancer diseases.
format article
author Yiwei Zhang
Handi Cao
Jie Chen
Yuanxin Li
Aimin Xu
Yu Wang
author_facet Yiwei Zhang
Handi Cao
Jie Chen
Yuanxin Li
Aimin Xu
Yu Wang
author_sort Yiwei Zhang
title Adiponectin-expressing Treg facilitate T lymphocyte development in thymic nurse cell complexes
title_short Adiponectin-expressing Treg facilitate T lymphocyte development in thymic nurse cell complexes
title_full Adiponectin-expressing Treg facilitate T lymphocyte development in thymic nurse cell complexes
title_fullStr Adiponectin-expressing Treg facilitate T lymphocyte development in thymic nurse cell complexes
title_full_unstemmed Adiponectin-expressing Treg facilitate T lymphocyte development in thymic nurse cell complexes
title_sort adiponectin-expressing treg facilitate t lymphocyte development in thymic nurse cell complexes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/8e0492b178fa4e19bcae97039bdba8a0
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AT handicao adiponectinexpressingtregfacilitatetlymphocytedevelopmentinthymicnursecellcomplexes
AT jiechen adiponectinexpressingtregfacilitatetlymphocytedevelopmentinthymicnursecellcomplexes
AT yuanxinli adiponectinexpressingtregfacilitatetlymphocytedevelopmentinthymicnursecellcomplexes
AT aiminxu adiponectinexpressingtregfacilitatetlymphocytedevelopmentinthymicnursecellcomplexes
AT yuwang adiponectinexpressingtregfacilitatetlymphocytedevelopmentinthymicnursecellcomplexes
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