TDP-43 aggregation inside micronuclei reveals a potential mechanism for protein inclusion formation in ALS

TDP-43 aggregation inside micronuclei reveals a potential mechanism for protein inclusion formation in ALS

Abstract Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease with no known etiology. The formation of pathological protein inclusions, including RNA-binding proteins such as TDP-43 and rho guanine nucleotide exchange factor (RGNEF) are a hallmark of ALS. Despit...

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Autores principales: Cristian A. Droppelmann, Danae Campos-Melo, Alexander J. Moszczynski, Hind Amzil, Michael J. Strong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/8e05139623084174b31f8c9097aface9
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