EEG microstate analysis in drug-naive patients with panic disorder.

Patients with panic disorder (PD) have a bias to respond to normal stimuli in a fearful way. This may be due to the preactivation of fear-associated networks prior to stimulus perception. Based on EEG, we investigated the difference between patients with PD and normal controls in resting state activ...

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Autores principales:	Mitsuru Kikuchi, Thomas Koenig, Toshio Munesue, Akira Hanaoka, Werner Strik, Thomas Dierks, Yoshifumi Koshino, Yoshio Minabe
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e052f401bb64f91a34bc0810a7c2141
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id	oai:doaj.org-article:8e052f401bb64f91a34bc0810a7c2141
record_format	dspace
spelling	oai:doaj.org-article:8e052f401bb64f91a34bc0810a7c21412021-11-18T06:48:59ZEEG microstate analysis in drug-naive patients with panic disorder.1932-620310.1371/journal.pone.0022912https://doaj.org/article/8e052f401bb64f91a34bc0810a7c21412011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21829554/?tool=EBIhttps://doaj.org/toc/1932-6203Patients with panic disorder (PD) have a bias to respond to normal stimuli in a fearful way. This may be due to the preactivation of fear-associated networks prior to stimulus perception. Based on EEG, we investigated the difference between patients with PD and normal controls in resting state activity using features of transiently stable brain states (microstates). EEGs from 18 drug-naive patients and 18 healthy controls were analyzed. Microstate analysis showed that one class of microstates (with a right-anterior to left-posterior orientation of the mapped field) displayed longer durations and covered more of the total time in the patients than controls. Another microstate class (with a symmetric, anterior-posterior orientation) was observed less frequently in the patients compared to controls. The observation that selected microstate classes differ between patients with PD and controls suggests that specific brain functions are altered already during resting condition. The altered resting state may be the starting point of the observed dysfunctional processing of phobic stimuli.Mitsuru KikuchiThomas KoenigToshio MunesueAkira HanaokaWerner StrikThomas DierksYoshifumi KoshinoYoshio MinabePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22912 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mitsuru Kikuchi Thomas Koenig Toshio Munesue Akira Hanaoka Werner Strik Thomas Dierks Yoshifumi Koshino Yoshio Minabe EEG microstate analysis in drug-naive patients with panic disorder.
description	Patients with panic disorder (PD) have a bias to respond to normal stimuli in a fearful way. This may be due to the preactivation of fear-associated networks prior to stimulus perception. Based on EEG, we investigated the difference between patients with PD and normal controls in resting state activity using features of transiently stable brain states (microstates). EEGs from 18 drug-naive patients and 18 healthy controls were analyzed. Microstate analysis showed that one class of microstates (with a right-anterior to left-posterior orientation of the mapped field) displayed longer durations and covered more of the total time in the patients than controls. Another microstate class (with a symmetric, anterior-posterior orientation) was observed less frequently in the patients compared to controls. The observation that selected microstate classes differ between patients with PD and controls suggests that specific brain functions are altered already during resting condition. The altered resting state may be the starting point of the observed dysfunctional processing of phobic stimuli.
format	article
author	Mitsuru Kikuchi Thomas Koenig Toshio Munesue Akira Hanaoka Werner Strik Thomas Dierks Yoshifumi Koshino Yoshio Minabe
author_facet	Mitsuru Kikuchi Thomas Koenig Toshio Munesue Akira Hanaoka Werner Strik Thomas Dierks Yoshifumi Koshino Yoshio Minabe
author_sort	Mitsuru Kikuchi
title	EEG microstate analysis in drug-naive patients with panic disorder.
title_short	EEG microstate analysis in drug-naive patients with panic disorder.
title_full	EEG microstate analysis in drug-naive patients with panic disorder.
title_fullStr	EEG microstate analysis in drug-naive patients with panic disorder.
title_full_unstemmed	EEG microstate analysis in drug-naive patients with panic disorder.
title_sort	eeg microstate analysis in drug-naive patients with panic disorder.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/8e052f401bb64f91a34bc0810a7c2141
work_keys_str_mv	AT mitsurukikuchi eegmicrostateanalysisindrugnaivepatientswithpanicdisorder AT thomaskoenig eegmicrostateanalysisindrugnaivepatientswithpanicdisorder AT toshiomunesue eegmicrostateanalysisindrugnaivepatientswithpanicdisorder AT akirahanaoka eegmicrostateanalysisindrugnaivepatientswithpanicdisorder AT wernerstrik eegmicrostateanalysisindrugnaivepatientswithpanicdisorder AT thomasdierks eegmicrostateanalysisindrugnaivepatientswithpanicdisorder AT yoshifumikoshino eegmicrostateanalysisindrugnaivepatientswithpanicdisorder AT yoshiominabe eegmicrostateanalysisindrugnaivepatientswithpanicdisorder
_version_	1718424364690440192

EEG microstate analysis in drug-naive patients with panic disorder.

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