Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis

Abstract The morbidity and mortality of cryptococcal meningoencephalitis (CM) in previously healthy, HIV-negative individuals is increasingly recognized. We administered a healthcare associated quality of life (QOL) survey to the largest longitudinally followed cohort of these patients in the United...

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Autores principales:	Owen Dean, Seher Anjum, Terri Scott, Lillian Ham, Katherine Traino, Jing Wang, Sally Hunsberger, John H. Powers, Kieren A. Marr, Joseph Snow, Peter R. Williamson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e07571315a1452d9ea771c009230419
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spelling	oai:doaj.org-article:8e07571315a1452d9ea771c0092304192021-12-02T12:15:02ZQuality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis10.1038/s41598-021-83176-22045-2322https://doaj.org/article/8e07571315a1452d9ea771c0092304192021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83176-2https://doaj.org/toc/2045-2322Abstract The morbidity and mortality of cryptococcal meningoencephalitis (CM) in previously healthy, HIV-negative individuals is increasingly recognized. We administered a healthcare associated quality of life (QOL) survey to the largest longitudinally followed cohort of these patients in the United States. We identified moderate or severe self-reported impairment in at least one QOL domain in 61% of subjects at least one year following diagnosis. Self-reported cognitive impairment was noted in 52% and sleep disturbance was noted in 55%. This is the first comprehensive study of cross-sectional long-term QOL in previously healthy patients following cryptococcal infection.Owen DeanSeher AnjumTerri ScottLillian HamKatherine TrainoJing WangSally HunsbergerJohn H. PowersKieren A. MarrJoseph SnowPeter R. WilliamsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Owen Dean Seher Anjum Terri Scott Lillian Ham Katherine Traino Jing Wang Sally Hunsberger John H. Powers Kieren A. Marr Joseph Snow Peter R. Williamson Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis
description	Abstract The morbidity and mortality of cryptococcal meningoencephalitis (CM) in previously healthy, HIV-negative individuals is increasingly recognized. We administered a healthcare associated quality of life (QOL) survey to the largest longitudinally followed cohort of these patients in the United States. We identified moderate or severe self-reported impairment in at least one QOL domain in 61% of subjects at least one year following diagnosis. Self-reported cognitive impairment was noted in 52% and sleep disturbance was noted in 55%. This is the first comprehensive study of cross-sectional long-term QOL in previously healthy patients following cryptococcal infection.
format	article
author	Owen Dean Seher Anjum Terri Scott Lillian Ham Katherine Traino Jing Wang Sally Hunsberger John H. Powers Kieren A. Marr Joseph Snow Peter R. Williamson
author_facet	Owen Dean Seher Anjum Terri Scott Lillian Ham Katherine Traino Jing Wang Sally Hunsberger John H. Powers Kieren A. Marr Joseph Snow Peter R. Williamson
author_sort	Owen Dean
title	Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis
title_short	Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis
title_full	Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis
title_fullStr	Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis
title_full_unstemmed	Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis
title_sort	quality of life of hiv-negative, previously healthy individuals following cryptococcal meningoencephalitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8e07571315a1452d9ea771c009230419
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Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis

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