Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes

Impaired beta-cell insulin secretion is a key pathological feature of type 2 diabetes. Here, the authors describe metabolic stress induced lysosomal degradation of newly formed insulin granules, independent of macroautophagy, as a potential mechanism for beta-cell dysfunction.

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Autores principales:	Adrien Pasquier, Kevin Vivot, Eric Erbs, Coralie Spiegelhalter, Zhirong Zhang, Victor Aubert, Zengzhen Liu, Meryem Senkara, Elisa Maillard, Michel Pinget, Julie Kerr-Conte, François Pattou, Gilbert Marciniak, Axel Ganzhorn, Paolo Ronchi, Nicole L. Schieber, Yannick Schwab, Paul Saftig, Alexander Goginashvili, Romeo Ricci
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e0d2438f64c4863b27b51b83a65cf65
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spelling	oai:doaj.org-article:8e0d2438f64c4863b27b51b83a65cf652021-12-02T15:35:52ZLysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes10.1038/s41467-019-11170-42041-1723https://doaj.org/article/8e0d2438f64c4863b27b51b83a65cf652019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11170-4https://doaj.org/toc/2041-1723Impaired beta-cell insulin secretion is a key pathological feature of type 2 diabetes. Here, the authors describe metabolic stress induced lysosomal degradation of newly formed insulin granules, independent of macroautophagy, as a potential mechanism for beta-cell dysfunction.Adrien PasquierKevin VivotEric ErbsCoralie SpiegelhalterZhirong ZhangVictor AubertZengzhen LiuMeryem SenkaraElisa MaillardMichel PingetJulie Kerr-ConteFrançois PattouGilbert MarciniakAxel GanzhornPaolo RonchiNicole L. SchieberYannick SchwabPaul SaftigAlexander GoginashviliRomeo RicciNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adrien Pasquier Kevin Vivot Eric Erbs Coralie Spiegelhalter Zhirong Zhang Victor Aubert Zengzhen Liu Meryem Senkara Elisa Maillard Michel Pinget Julie Kerr-Conte François Pattou Gilbert Marciniak Axel Ganzhorn Paolo Ronchi Nicole L. Schieber Yannick Schwab Paul Saftig Alexander Goginashvili Romeo Ricci Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes
description	Impaired beta-cell insulin secretion is a key pathological feature of type 2 diabetes. Here, the authors describe metabolic stress induced lysosomal degradation of newly formed insulin granules, independent of macroautophagy, as a potential mechanism for beta-cell dysfunction.
format	article
author	Adrien Pasquier Kevin Vivot Eric Erbs Coralie Spiegelhalter Zhirong Zhang Victor Aubert Zengzhen Liu Meryem Senkara Elisa Maillard Michel Pinget Julie Kerr-Conte François Pattou Gilbert Marciniak Axel Ganzhorn Paolo Ronchi Nicole L. Schieber Yannick Schwab Paul Saftig Alexander Goginashvili Romeo Ricci
author_facet	Adrien Pasquier Kevin Vivot Eric Erbs Coralie Spiegelhalter Zhirong Zhang Victor Aubert Zengzhen Liu Meryem Senkara Elisa Maillard Michel Pinget Julie Kerr-Conte François Pattou Gilbert Marciniak Axel Ganzhorn Paolo Ronchi Nicole L. Schieber Yannick Schwab Paul Saftig Alexander Goginashvili Romeo Ricci
author_sort	Adrien Pasquier
title	Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes
title_short	Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes
title_full	Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes
title_fullStr	Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes
title_full_unstemmed	Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes
title_sort	lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8e0d2438f64c4863b27b51b83a65cf65
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Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes

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