Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes

Impaired beta-cell insulin secretion is a key pathological feature of type 2 diabetes. Here, the authors describe metabolic stress induced lysosomal degradation of newly formed insulin granules, independent of macroautophagy, as a potential mechanism for beta-cell dysfunction.

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Detalles Bibliográficos
Autores principales:	Adrien Pasquier, Kevin Vivot, Eric Erbs, Coralie Spiegelhalter, Zhirong Zhang, Victor Aubert, Zengzhen Liu, Meryem Senkara, Elisa Maillard, Michel Pinget, Julie Kerr-Conte, François Pattou, Gilbert Marciniak, Axel Ganzhorn, Paolo Ronchi, Nicole L. Schieber, Yannick Schwab, Paul Saftig, Alexander Goginashvili, Romeo Ricci
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e0d2438f64c4863b27b51b83a65cf65
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Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes

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