Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis

Introduction The aim of this meta-analysis was to summarize the evidence on the serum/plasma leptin concentrations in breast cancer (BC) patients, as well as the associations between leptin G-2548A gene polymorphisms and susceptibility to BC. Material and methods Potentially relevant studies about...

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Autores principales:	Ji-Qing Hao, Qian-Kun Zhang, Yi-Xin Zhou, Li-Hao Chen, Peng-Fei Wu
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	breast cancer leptin meta-analysis gene polymorphism Medicine R
Acceso en línea:	https://doaj.org/article/8e0dc41cf22840f29ac5d7fe2e7e5941
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spelling	oai:doaj.org-article:8e0dc41cf22840f29ac5d7fe2e7e59412021-12-02T19:15:49ZAssociation between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis1734-19221896-915110.5114/aoms.2018.75638https://doaj.org/article/8e0dc41cf22840f29ac5d7fe2e7e59412019-03-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Association-between-circulating-leptin-concentration-and-G-2548A-gene-polymorphism,89941,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction The aim of this meta-analysis was to summarize the evidence on the serum/plasma leptin concentrations in breast cancer (BC) patients, as well as the associations between leptin G-2548A gene polymorphisms and susceptibility to BC. Material and methods Potentially relevant studies about serum/plasma leptin levels and leptin G-2548A gene polymorphism were selected using the electronic databases PubMed, EMBASE and The Cochrane Library (from January 1 1995 to Jun 30 2017, no language restrictions). The potential sources of heterogeneity were assessed by the Q statistic and quantified using I 2 ; publication bias was qualitatively assessed by funnel plot and quantitatively assessed by Egger’s linear regression test. Results A total of 1141 articles were retrieved after database searches, and 27 studies with 9516 subjects (4542 BC patients/4974 controls) were finally included. The results indicated that BC patients had significantly higher leptin levels compared with healthy controls (SMD = 1.65, 95% CI: 1.21–2.09, p < 0.001), but there was no association between leptin G-2548A polymorphism and BC (OR = 1.05, 95% CI: 0.80–1.39, p = 0.722). Subgroup analyses demonstrated increased leptin levels in BC patients of different region, race, body mass index and waist circumference. Conclusions Our results revealed a significantly higher leptin level in BC patients than in healthy controls, but no association between leptin G-2548A polymorphism and BC susceptibility was found.Ji-Qing HaoQian-Kun ZhangYi-Xin ZhouLi-Hao ChenPeng-Fei WuTermedia Publishing Housearticlebreast cancerleptinmeta-analysisgene polymorphismMedicineRENArchives of Medical Science, Vol 15, Iss 2, Pp 275-283 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer leptin meta-analysis gene polymorphism Medicine R
spellingShingle	breast cancer leptin meta-analysis gene polymorphism Medicine R Ji-Qing Hao Qian-Kun Zhang Yi-Xin Zhou Li-Hao Chen Peng-Fei Wu Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis
description	Introduction The aim of this meta-analysis was to summarize the evidence on the serum/plasma leptin concentrations in breast cancer (BC) patients, as well as the associations between leptin G-2548A gene polymorphisms and susceptibility to BC. Material and methods Potentially relevant studies about serum/plasma leptin levels and leptin G-2548A gene polymorphism were selected using the electronic databases PubMed, EMBASE and The Cochrane Library (from January 1 1995 to Jun 30 2017, no language restrictions). The potential sources of heterogeneity were assessed by the Q statistic and quantified using I 2 ; publication bias was qualitatively assessed by funnel plot and quantitatively assessed by Egger’s linear regression test. Results A total of 1141 articles were retrieved after database searches, and 27 studies with 9516 subjects (4542 BC patients/4974 controls) were finally included. The results indicated that BC patients had significantly higher leptin levels compared with healthy controls (SMD = 1.65, 95% CI: 1.21–2.09, p < 0.001), but there was no association between leptin G-2548A polymorphism and BC (OR = 1.05, 95% CI: 0.80–1.39, p = 0.722). Subgroup analyses demonstrated increased leptin levels in BC patients of different region, race, body mass index and waist circumference. Conclusions Our results revealed a significantly higher leptin level in BC patients than in healthy controls, but no association between leptin G-2548A polymorphism and BC susceptibility was found.
format	article
author	Ji-Qing Hao Qian-Kun Zhang Yi-Xin Zhou Li-Hao Chen Peng-Fei Wu
author_facet	Ji-Qing Hao Qian-Kun Zhang Yi-Xin Zhou Li-Hao Chen Peng-Fei Wu
author_sort	Ji-Qing Hao
title	Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis
title_short	Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis
title_full	Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis
title_fullStr	Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis
title_full_unstemmed	Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis
title_sort	association between circulating leptin concentration and g-2548a gene polymorphism in patients with breast cancer: a meta-analysis
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/8e0dc41cf22840f29ac5d7fe2e7e5941
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Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis

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