Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth

Arginine methyltransferases (PRMTs) are involved in the regulation of various physiological and pathological conditions. Using proteomics, the authors here profile the methylation substrates of PRMTs 4, 5 and 7 and characterize the roles of these enzymes in cancer-associated splicing regulation.

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Autores principales:	Wen-juan Li, Yao-hui He, Jing-jing Yang, Guo-sheng Hu, Yi-an Lin, Ting Ran, Bing-ling Peng, Bing-lan Xie, Ming-feng Huang, Xiang Gao, Hai-hua Huang, Helen He Zhu, Feng Ye, Wen Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e1165b1d3b04a91a453caaef784fec5
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spelling	oai:doaj.org-article:8e1165b1d3b04a91a453caaef784fec52021-12-02T13:26:41ZProfiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth10.1038/s41467-021-21963-12041-1723https://doaj.org/article/8e1165b1d3b04a91a453caaef784fec52021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21963-1https://doaj.org/toc/2041-1723Arginine methyltransferases (PRMTs) are involved in the regulation of various physiological and pathological conditions. Using proteomics, the authors here profile the methylation substrates of PRMTs 4, 5 and 7 and characterize the roles of these enzymes in cancer-associated splicing regulation.Wen-juan LiYao-hui HeJing-jing YangGuo-sheng HuYi-an LinTing RanBing-ling PengBing-lan XieMing-feng HuangXiang GaoHai-hua HuangHelen He ZhuFeng YeWen LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen-juan Li Yao-hui He Jing-jing Yang Guo-sheng Hu Yi-an Lin Ting Ran Bing-ling Peng Bing-lan Xie Ming-feng Huang Xiang Gao Hai-hua Huang Helen He Zhu Feng Ye Wen Liu Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth
description	Arginine methyltransferases (PRMTs) are involved in the regulation of various physiological and pathological conditions. Using proteomics, the authors here profile the methylation substrates of PRMTs 4, 5 and 7 and characterize the roles of these enzymes in cancer-associated splicing regulation.
format	article
author	Wen-juan Li Yao-hui He Jing-jing Yang Guo-sheng Hu Yi-an Lin Ting Ran Bing-ling Peng Bing-lan Xie Ming-feng Huang Xiang Gao Hai-hua Huang Helen He Zhu Feng Ye Wen Liu
author_facet	Wen-juan Li Yao-hui He Jing-jing Yang Guo-sheng Hu Yi-an Lin Ting Ran Bing-ling Peng Bing-lan Xie Ming-feng Huang Xiang Gao Hai-hua Huang Helen He Zhu Feng Ye Wen Liu
author_sort	Wen-juan Li
title	Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth
title_short	Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth
title_full	Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth
title_fullStr	Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth
title_full_unstemmed	Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth
title_sort	profiling prmt methylome reveals roles of hnrnpa1 arginine methylation in rna splicing and cell growth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8e1165b1d3b04a91a453caaef784fec5
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Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth

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