Centrality in the host–pathogen interactome is associated with pathogen fitness during infection

Hubs tend to be essential for function in protein networks within organisms. Here, the authors show that during infection, it is the proteins with high centrality in theY. pestishost–pathogen interactome that are most important for pathogen fitness during infection, and highlight the importance of p...

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Autores principales:	Núria Crua Asensio, Elisabet Muñoz Giner, Natalia Sánchez de Groot, Marc Torrent Burgas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e14028edd104ce1ba423ab6ea6636e1
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spelling	oai:doaj.org-article:8e14028edd104ce1ba423ab6ea6636e12021-12-02T14:41:18ZCentrality in the host–pathogen interactome is associated with pathogen fitness during infection10.1038/ncomms140922041-1723https://doaj.org/article/8e14028edd104ce1ba423ab6ea6636e12017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14092https://doaj.org/toc/2041-1723Hubs tend to be essential for function in protein networks within organisms. Here, the authors show that during infection, it is the proteins with high centrality in theY. pestishost–pathogen interactome that are most important for pathogen fitness during infection, and highlight the importance of pathogen proteins that likely cause significant perturbation of the host interactome.Núria Crua AsensioElisabet Muñoz GinerNatalia Sánchez de GrootMarc Torrent BurgasNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Núria Crua Asensio Elisabet Muñoz Giner Natalia Sánchez de Groot Marc Torrent Burgas Centrality in the host–pathogen interactome is associated with pathogen fitness during infection
description	Hubs tend to be essential for function in protein networks within organisms. Here, the authors show that during infection, it is the proteins with high centrality in theY. pestishost–pathogen interactome that are most important for pathogen fitness during infection, and highlight the importance of pathogen proteins that likely cause significant perturbation of the host interactome.
format	article
author	Núria Crua Asensio Elisabet Muñoz Giner Natalia Sánchez de Groot Marc Torrent Burgas
author_facet	Núria Crua Asensio Elisabet Muñoz Giner Natalia Sánchez de Groot Marc Torrent Burgas
author_sort	Núria Crua Asensio
title	Centrality in the host–pathogen interactome is associated with pathogen fitness during infection
title_short	Centrality in the host–pathogen interactome is associated with pathogen fitness during infection
title_full	Centrality in the host–pathogen interactome is associated with pathogen fitness during infection
title_fullStr	Centrality in the host–pathogen interactome is associated with pathogen fitness during infection
title_full_unstemmed	Centrality in the host–pathogen interactome is associated with pathogen fitness during infection
title_sort	centrality in the host–pathogen interactome is associated with pathogen fitness during infection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8e14028edd104ce1ba423ab6ea6636e1
work_keys_str_mv	AT nuriacruaasensio centralityinthehostpathogeninteractomeisassociatedwithpathogenfitnessduringinfection AT elisabetmunozginer centralityinthehostpathogeninteractomeisassociatedwithpathogenfitnessduringinfection AT nataliasanchezdegroot centralityinthehostpathogeninteractomeisassociatedwithpathogenfitnessduringinfection AT marctorrentburgas centralityinthehostpathogeninteractomeisassociatedwithpathogenfitnessduringinfection
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Centrality in the host–pathogen interactome is associated with pathogen fitness during infection

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