Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate

Antiviral defence type III CRISPR systems produce cyclic oligoadenylates (cOA) as second messengers that activate downstream effectors. Here the authors present the crystal structure of the type III CRISPR defence DNA nuclease Can1 in complex with cyclic tetra-adenylate (cA4) and show that Can1 nick...

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Autores principales:	Stephen A. McMahon, Wenlong Zhu, Shirley Graham, Robert Rambo, Malcolm F. White, Tracey M. Gloster
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e15c55ed2f04a3986e306637192568c
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spelling	oai:doaj.org-article:8e15c55ed2f04a3986e306637192568c2021-12-02T17:31:23ZStructure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate10.1038/s41467-019-14222-x2041-1723https://doaj.org/article/8e15c55ed2f04a3986e306637192568c2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14222-xhttps://doaj.org/toc/2041-1723Antiviral defence type III CRISPR systems produce cyclic oligoadenylates (cOA) as second messengers that activate downstream effectors. Here the authors present the crystal structure of the type III CRISPR defence DNA nuclease Can1 in complex with cyclic tetra-adenylate (cA4) and show that Can1 nicks supercoiled DNA.Stephen A. McMahonWenlong ZhuShirley GrahamRobert RamboMalcolm F. WhiteTracey M. GlosterNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen A. McMahon Wenlong Zhu Shirley Graham Robert Rambo Malcolm F. White Tracey M. Gloster Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
description	Antiviral defence type III CRISPR systems produce cyclic oligoadenylates (cOA) as second messengers that activate downstream effectors. Here the authors present the crystal structure of the type III CRISPR defence DNA nuclease Can1 in complex with cyclic tetra-adenylate (cA4) and show that Can1 nicks supercoiled DNA.
format	article
author	Stephen A. McMahon Wenlong Zhu Shirley Graham Robert Rambo Malcolm F. White Tracey M. Gloster
author_facet	Stephen A. McMahon Wenlong Zhu Shirley Graham Robert Rambo Malcolm F. White Tracey M. Gloster
author_sort	Stephen A. McMahon
title	Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
title_short	Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
title_full	Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
title_fullStr	Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
title_full_unstemmed	Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
title_sort	structure and mechanism of a type iii crispr defence dna nuclease activated by cyclic oligoadenylate
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8e15c55ed2f04a3986e306637192568c
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Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate

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