Efficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery

Efficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery

Abstract To optimize gene delivery to myelinating Schwann cells we compared clinically relevant AAV serotypes and injection routes. AAV9 and AAVrh10 vectors expressing either EGFP or the neuropathy-associated gene GJB1/Connexin32 (Cx32) under a myelin specific promoter were injected intrathecally or...

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Autores principales: A. Kagiava, J. Richter, C. Tryfonos, M. Leal-Julià, I. Sargiannidou, C. Christodoulou, A. Bosch, K. A. Kleopa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/8e16780b5a43469086b07ce6b9a5240d
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