Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies

Cervical cancer is the fourth common gynecologic cancer and is considered as second leading cause of death among women. Various strategies are applied in treatment of cervical cancer including radiotherapy, chemotherapy and surgery. However, cervical cancer cells demonstrate aggressive behavior in a...

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Autores principales:	Mahshid Deldar Abad Paskeh, Sepideh Mirzaei, Mohammad Hossein Gholami, Ali Zarrabi, Amirhossein Zabolian, Mehrdad Hashemi, Kiavash Hushmandi, Milad Ashrafizadeh, Amir Reza Aref, Saeed Samarghandian
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cervical cancer SOX transcription factor Biomarker Chemoresistance Cancer therapy Non-coding RNAs Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8e171ef467504a1d994cbd948808b369
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spelling	oai:doaj.org-article:8e171ef467504a1d994cbd948808b3692021-11-14T04:29:56ZCervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies0753-332210.1016/j.biopha.2021.112335https://doaj.org/article/8e171ef467504a1d994cbd948808b3692021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011197https://doaj.org/toc/0753-3322Cervical cancer is the fourth common gynecologic cancer and is considered as second leading cause of death among women. Various strategies are applied in treatment of cervical cancer including radiotherapy, chemotherapy and surgery. However, cervical cancer cells demonstrate aggressive behavior in advanced phases, requiring novel strategies in their elimination. On the other hand, SOX proteins are transcription factors capable of regulating different molecular pathways and their expression varies during embryogenesis, disease development and carcinogenesis. In the present review, our aim is to reveal role of SOX transcription factors in cervical cancer. SOX transcription factors play like a double-edged sword in cancer. For instance, SOX9 possesses both tumor-suppressor and tumor-promoting role in cervical cancer. Therefore, exact role of each SOX members in cervical cancer has been discussed to direct further experiments for revealing other functions. SOX proteins can regulate proliferation and metastasis of cervical cancer cells. Furthermore, response of cervical cancer cells to chemotherapy and radiotherapy is tightly regulated by SOX transcription factors. Different downstream targets of SOX proteins such as Wnt signaling, EMT and Hedgehog have been identified. Besides, upstream mediators such as microRNAs, lncRNAs and circRNAs can regulate SOX expression in cervical cancer. In addition to pre-clinical studies, role of SOX transcription factors as prognostic and diagnostic tools in cervical cancer has been shown.Mahshid Deldar Abad PaskehSepideh MirzaeiMohammad Hossein GholamiAli ZarrabiAmirhossein ZabolianMehrdad HashemiKiavash HushmandiMilad AshrafizadehAmir Reza ArefSaeed SamarghandianElsevierarticleCervical cancerSOX transcription factorBiomarkerChemoresistanceCancer therapyNon-coding RNAsTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112335- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cervical cancer SOX transcription factor Biomarker Chemoresistance Cancer therapy Non-coding RNAs Therapeutics. Pharmacology RM1-950
spellingShingle	Cervical cancer SOX transcription factor Biomarker Chemoresistance Cancer therapy Non-coding RNAs Therapeutics. Pharmacology RM1-950 Mahshid Deldar Abad Paskeh Sepideh Mirzaei Mohammad Hossein Gholami Ali Zarrabi Amirhossein Zabolian Mehrdad Hashemi Kiavash Hushmandi Milad Ashrafizadeh Amir Reza Aref Saeed Samarghandian Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies
description	Cervical cancer is the fourth common gynecologic cancer and is considered as second leading cause of death among women. Various strategies are applied in treatment of cervical cancer including radiotherapy, chemotherapy and surgery. However, cervical cancer cells demonstrate aggressive behavior in advanced phases, requiring novel strategies in their elimination. On the other hand, SOX proteins are transcription factors capable of regulating different molecular pathways and their expression varies during embryogenesis, disease development and carcinogenesis. In the present review, our aim is to reveal role of SOX transcription factors in cervical cancer. SOX transcription factors play like a double-edged sword in cancer. For instance, SOX9 possesses both tumor-suppressor and tumor-promoting role in cervical cancer. Therefore, exact role of each SOX members in cervical cancer has been discussed to direct further experiments for revealing other functions. SOX proteins can regulate proliferation and metastasis of cervical cancer cells. Furthermore, response of cervical cancer cells to chemotherapy and radiotherapy is tightly regulated by SOX transcription factors. Different downstream targets of SOX proteins such as Wnt signaling, EMT and Hedgehog have been identified. Besides, upstream mediators such as microRNAs, lncRNAs and circRNAs can regulate SOX expression in cervical cancer. In addition to pre-clinical studies, role of SOX transcription factors as prognostic and diagnostic tools in cervical cancer has been shown.
format	article
author	Mahshid Deldar Abad Paskeh Sepideh Mirzaei Mohammad Hossein Gholami Ali Zarrabi Amirhossein Zabolian Mehrdad Hashemi Kiavash Hushmandi Milad Ashrafizadeh Amir Reza Aref Saeed Samarghandian
author_facet	Mahshid Deldar Abad Paskeh Sepideh Mirzaei Mohammad Hossein Gholami Ali Zarrabi Amirhossein Zabolian Mehrdad Hashemi Kiavash Hushmandi Milad Ashrafizadeh Amir Reza Aref Saeed Samarghandian
author_sort	Mahshid Deldar Abad Paskeh
title	Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies
title_short	Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies
title_full	Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies
title_fullStr	Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies
title_full_unstemmed	Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies
title_sort	cervical cancer progression is regulated by sox transcription factors: revealing signaling networks and therapeutic strategies
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8e171ef467504a1d994cbd948808b369
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Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies

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