GENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS

There is a genetic predisposition to psoriasis (PS) and psoriatic arthritis (PsA), in which some cytokine genes are involved. Identification of polymorphic variants of immune response genes (i.e.,cytokines and their specific receptors) is a promising direction for studies of genetic risk factors res...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M. V. Smolnikova, S. V. Smirnova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	psoriasis psoriatic arthritis gene polymorphism cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8e206c1da96943fbacd8c5bb635f37dd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8e206c1da96943fbacd8c5bb635f37dd
record_format	dspace
spelling	oai:doaj.org-article:8e206c1da96943fbacd8c5bb635f37dd2021-11-18T08:03:43ZGENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS1563-06252313-741X10.15789/1563-0625-2014-3-211-220https://doaj.org/article/8e206c1da96943fbacd8c5bb635f37dd2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/686https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThere is a genetic predisposition to psoriasis (PS) and psoriatic arthritis (PsA), in which some cytokine genes are involved. Identification of polymorphic variants of immune response genes (i.e.,cytokines and their specific receptors) is a promising direction for studies of genetic risk factors responsible for development of skin and joint inflammation in psoriasis and PsA. Immune disorders characterized by the deviation of cytokine profile by Th1-type (IL-2, IFNγ, TNFα) play a leading role in immunopathogenesis ofpsoriasis and psoriatic arthritis. The review deals with analysis of publications regarding the role of cytokine gene polymorphisms associated with clinical course of psoriasis and PsA. Further search for genetic markersdetermining clinical risks of PS and PsA would be an important step in personalized approach to prediction of occurrence and clinical course of the disease, as well as to arrangement of preventive measures, in order to prevent potential progression of the disease.M. V. SmolnikovaS. V. SmirnovaSPb RAACIarticlepsoriasispsoriatic arthritisgene polymorphismcytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 3, Pp 211-220 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	psoriasis psoriatic arthritis gene polymorphism cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	psoriasis psoriatic arthritis gene polymorphism cytokines Immunologic diseases. Allergy RC581-607 M. V. Smolnikova S. V. Smirnova GENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
description	There is a genetic predisposition to psoriasis (PS) and psoriatic arthritis (PsA), in which some cytokine genes are involved. Identification of polymorphic variants of immune response genes (i.e.,cytokines and their specific receptors) is a promising direction for studies of genetic risk factors responsible for development of skin and joint inflammation in psoriasis and PsA. Immune disorders characterized by the deviation of cytokine profile by Th1-type (IL-2, IFNγ, TNFα) play a leading role in immunopathogenesis ofpsoriasis and psoriatic arthritis. The review deals with analysis of publications regarding the role of cytokine gene polymorphisms associated with clinical course of psoriasis and PsA. Further search for genetic markersdetermining clinical risks of PS and PsA would be an important step in personalized approach to prediction of occurrence and clinical course of the disease, as well as to arrangement of preventive measures, in order to prevent potential progression of the disease.
format	article
author	M. V. Smolnikova S. V. Smirnova
author_facet	M. V. Smolnikova S. V. Smirnova
author_sort	M. V. Smolnikova
title	GENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
title_short	GENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
title_full	GENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
title_fullStr	GENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
title_full_unstemmed	GENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
title_sort	genetic factors in immunopathogenesis of psoriasis and psoriatic arthritis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8e206c1da96943fbacd8c5bb635f37dd
work_keys_str_mv	AT mvsmolnikova geneticfactorsinimmunopathogenesisofpsoriasisandpsoriaticarthritis AT svsmirnova geneticfactorsinimmunopathogenesisofpsoriasisandpsoriaticarthritis
_version_	1718422433975762944

GENETIC FACTORS IN IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS

Ejemplares similares