RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection.

NF-κB transcription factors are crucial for many cellular processes. NF-κB is activated by viral infections to induce expression of antiviral cytokines. Here, we identified a novel member of the human NF-κB family, denoted RelAp43, the nucleotide sequence of which contains several exons as well as a...

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Autores principales:	Sophie Luco, Olivier Delmas, Pierre-Olivier Vidalain, Frédéric Tangy, Robert Weil, Hervé Bourhy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8e25f8639f16407db812b249801d6125
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spelling	oai:doaj.org-article:8e25f8639f16407db812b249801d61252021-11-18T06:06:15ZRelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection.1553-73661553-737410.1371/journal.ppat.1003060https://doaj.org/article/8e25f8639f16407db812b249801d61252012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23271966/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374NF-κB transcription factors are crucial for many cellular processes. NF-κB is activated by viral infections to induce expression of antiviral cytokines. Here, we identified a novel member of the human NF-κB family, denoted RelAp43, the nucleotide sequence of which contains several exons as well as an intron of the RelA gene. RelAp43 is expressed in all cell lines and tissues tested and exhibits all the properties of a NF-κB protein. Although its sequence does not include a transactivation domain, identifying it as a class I member of the NF-κB family, it is able to potentiate RelA-mediated transactivation and stabilize dimers comprising p50. Furthermore, RelAp43 stimulates the expression of HIAP1, IRF1, and IFN-β - three genes involved in cell immunity against viral infection. It is also targeted by the matrix protein of lyssaviruses, the agents of rabies, resulting in an inhibition of the NF-κB pathway. Taken together, our data provide the description of a novel functional member of the NF-κB family, which plays a key role in the induction of anti-viral innate immune response.Sophie LucoOlivier DelmasPierre-Olivier VidalainFrédéric TangyRobert WeilHervé BourhyPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 8, Iss 12, p e1003060 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Sophie Luco Olivier Delmas Pierre-Olivier Vidalain Frédéric Tangy Robert Weil Hervé Bourhy RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection.
description	NF-κB transcription factors are crucial for many cellular processes. NF-κB is activated by viral infections to induce expression of antiviral cytokines. Here, we identified a novel member of the human NF-κB family, denoted RelAp43, the nucleotide sequence of which contains several exons as well as an intron of the RelA gene. RelAp43 is expressed in all cell lines and tissues tested and exhibits all the properties of a NF-κB protein. Although its sequence does not include a transactivation domain, identifying it as a class I member of the NF-κB family, it is able to potentiate RelA-mediated transactivation and stabilize dimers comprising p50. Furthermore, RelAp43 stimulates the expression of HIAP1, IRF1, and IFN-β - three genes involved in cell immunity against viral infection. It is also targeted by the matrix protein of lyssaviruses, the agents of rabies, resulting in an inhibition of the NF-κB pathway. Taken together, our data provide the description of a novel functional member of the NF-κB family, which plays a key role in the induction of anti-viral innate immune response.
format	article
author	Sophie Luco Olivier Delmas Pierre-Olivier Vidalain Frédéric Tangy Robert Weil Hervé Bourhy
author_facet	Sophie Luco Olivier Delmas Pierre-Olivier Vidalain Frédéric Tangy Robert Weil Hervé Bourhy
author_sort	Sophie Luco
title	RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection.
title_short	RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection.
title_full	RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection.
title_fullStr	RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection.
title_full_unstemmed	RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection.
title_sort	relap43, a member of the nf-κb family involved in innate immune response against lyssavirus infection.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/8e25f8639f16407db812b249801d6125
work_keys_str_mv	AT sophieluco relap43amemberofthenfkbfamilyinvolvedininnateimmuneresponseagainstlyssavirusinfection AT olivierdelmas relap43amemberofthenfkbfamilyinvolvedininnateimmuneresponseagainstlyssavirusinfection AT pierreoliviervidalain relap43amemberofthenfkbfamilyinvolvedininnateimmuneresponseagainstlyssavirusinfection AT frederictangy relap43amemberofthenfkbfamilyinvolvedininnateimmuneresponseagainstlyssavirusinfection AT robertweil relap43amemberofthenfkbfamilyinvolvedininnateimmuneresponseagainstlyssavirusinfection AT hervebourhy relap43amemberofthenfkbfamilyinvolvedininnateimmuneresponseagainstlyssavirusinfection
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RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection.

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