Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization

Abstract Although choriocapillaris flow deficit (CFD) around choroidal neovascularization (CNV) is less associated with CNV activity in myopic eyes, no reports are investigating its size as an indicator of CNV activity. We investigated the relationship between CFD and high myopia-related CNV. In thi...

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Autores principales:	Sato Uematsu, Hirokazu Sakaguchi, Kaori Sayanagi, Yasushi Ikuno, Ayako Yokoyama, Tomoko Asai, Yoko Fukushima, Chikako Hara, Susumu Sakimoto, Kohji Nishida
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e276f9732fe46fc863fbf3c2283680e
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spelling	oai:doaj.org-article:8e276f9732fe46fc863fbf3c2283680e2021-11-14T12:19:42ZAssociation between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization10.1038/s41598-021-01557-z2045-2322https://doaj.org/article/8e276f9732fe46fc863fbf3c2283680e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01557-zhttps://doaj.org/toc/2045-2322Abstract Although choriocapillaris flow deficit (CFD) around choroidal neovascularization (CNV) is less associated with CNV activity in myopic eyes, no reports are investigating its size as an indicator of CNV activity. We investigated the relationship between CFD and high myopia-related CNV. In this retrospective, observational study, patients underwent optical coherence tomography angiography (OCTA) with split-spectrum amplitude-decorrelation angiography for diagnosing pathological myopic CNV (mCNV); CFD features around CNV margins were evaluated. Of the 33 eyes (30 patients), 11 (33.3%) had active mCNV, and 22 (66.7%) had inactive CNV. Six eyes (18.2%) were treatment-naïve, while the remainder previously underwent anti-vascular endothelial growth factor therapy. On OCTA, blood flow signals were detected in CNV in the outer retinal layer in 28 (84.8%) eyes, including all active cases (11 cases) and 17 (77.3%) of 22 inactive cases. CNV flow signal size correlated significantly with activity (P < 0.001). CFD around CNV was observed in 24 eyes (72.7%), including all active cases (11 cases) and 13 (59.1%) of 22 inactive cases. CFD size correlated significantly with CNV activity (P < 0.001). The size of both the CFD area around CNV and CNV flow signal area are useful indicators of CNV activity in eyes with mCNV, which may help determine treatment timing.Sato UematsuHirokazu SakaguchiKaori SayanagiYasushi IkunoAyako YokoyamaTomoko AsaiYoko FukushimaChikako HaraSusumu SakimotoKohji NishidaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sato Uematsu Hirokazu Sakaguchi Kaori Sayanagi Yasushi Ikuno Ayako Yokoyama Tomoko Asai Yoko Fukushima Chikako Hara Susumu Sakimoto Kohji Nishida Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization
description	Abstract Although choriocapillaris flow deficit (CFD) around choroidal neovascularization (CNV) is less associated with CNV activity in myopic eyes, no reports are investigating its size as an indicator of CNV activity. We investigated the relationship between CFD and high myopia-related CNV. In this retrospective, observational study, patients underwent optical coherence tomography angiography (OCTA) with split-spectrum amplitude-decorrelation angiography for diagnosing pathological myopic CNV (mCNV); CFD features around CNV margins were evaluated. Of the 33 eyes (30 patients), 11 (33.3%) had active mCNV, and 22 (66.7%) had inactive CNV. Six eyes (18.2%) were treatment-naïve, while the remainder previously underwent anti-vascular endothelial growth factor therapy. On OCTA, blood flow signals were detected in CNV in the outer retinal layer in 28 (84.8%) eyes, including all active cases (11 cases) and 17 (77.3%) of 22 inactive cases. CNV flow signal size correlated significantly with activity (P < 0.001). CFD around CNV was observed in 24 eyes (72.7%), including all active cases (11 cases) and 13 (59.1%) of 22 inactive cases. CFD size correlated significantly with CNV activity (P < 0.001). The size of both the CFD area around CNV and CNV flow signal area are useful indicators of CNV activity in eyes with mCNV, which may help determine treatment timing.
format	article
author	Sato Uematsu Hirokazu Sakaguchi Kaori Sayanagi Yasushi Ikuno Ayako Yokoyama Tomoko Asai Yoko Fukushima Chikako Hara Susumu Sakimoto Kohji Nishida
author_facet	Sato Uematsu Hirokazu Sakaguchi Kaori Sayanagi Yasushi Ikuno Ayako Yokoyama Tomoko Asai Yoko Fukushima Chikako Hara Susumu Sakimoto Kohji Nishida
author_sort	Sato Uematsu
title	Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization
title_short	Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization
title_full	Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization
title_fullStr	Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization
title_full_unstemmed	Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization
title_sort	association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8e276f9732fe46fc863fbf3c2283680e
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Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization

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