Mercaptophos impacts on redox status biomarkers of common carp (Cyprinus carpio) as an endocrine disruptor

Endocrine-disrupting chemicals (EDCs) are compounds that affect the way the endocrine system works in both humans and animals. The emphasis of the research was on the negative effects of mercaptophos exposure on Cyprinus carpio. Fish were subjected to sub-lethal amounts of mercaptophos at low (0.83 ...

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Autores principales:	Asma W. Al-Thomali, Hend M. Tag, Amaal Mohammadein, Nahla S. El-Shenawy, Mohamed Salah El-Naggar
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Oxidative stress Antioxidant Histology Hormones Aquaculture. Fisheries. Angling SH1-691
Acceso en línea:	https://doaj.org/article/8e2824da5f984d148450f293e33c67d0
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spelling	oai:doaj.org-article:8e2824da5f984d148450f293e33c67d02021-12-04T04:35:16ZMercaptophos impacts on redox status biomarkers of common carp (Cyprinus carpio) as an endocrine disruptor2352-513410.1016/j.aqrep.2021.100959https://doaj.org/article/8e2824da5f984d148450f293e33c67d02022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352513421003768https://doaj.org/toc/2352-5134Endocrine-disrupting chemicals (EDCs) are compounds that affect the way the endocrine system works in both humans and animals. The emphasis of the research was on the negative effects of mercaptophos exposure on Cyprinus carpio. Fish were subjected to sub-lethal amounts of mercaptophos at low (0.83 ppm) and high (2.1 ppm) concentrations for 12, 24, 48, and 96 h. The levels of lipid peroxidation (LPO), protein carbonyl (PC), and glutathione (GSH) were tested in the fish liver. Plasma cortisol and testosterone levels, as well as a histological examination of liver tissue, were also assessed. C. carpio treated with mercaptophos had lower testosterone levels and higher cortisol levels at all time intervals. Mercaptophos exhibited oxidative stress in C. carpio, which causes a time-and concentration-dependent augmentation of liver LPO and PC levels, which is linked to hepatic GSH depletion. A low concentration of mercaptophos caused atrophy of pancreatic acinar cells as well as the detection of karyolysis nuclei, according to histological alterations in hepatic tissue. Treatment with a high dosage of mercaptophos resulted in hypertrophy of Kupffer cells as well as coagulative necrosis of pancreatic tissue. Furthermore, short-term mercaptophos exposure reduced testosterone and cortisol levels in C. carpio, which are associated with the development of oxidative stress. Changes in hormone levels and oxidative stress markers in C. carpio may therefore aid in the prediction of disease.Asma W. Al-ThomaliHend M. TagAmaal MohammadeinNahla S. El-ShenawyMohamed Salah El-NaggarElsevierarticleOxidative stressAntioxidantHistologyHormonesAquaculture. Fisheries. AnglingSH1-691ENAquaculture Reports, Vol 22, Iss , Pp 100959- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oxidative stress Antioxidant Histology Hormones Aquaculture. Fisheries. Angling SH1-691
spellingShingle	Oxidative stress Antioxidant Histology Hormones Aquaculture. Fisheries. Angling SH1-691 Asma W. Al-Thomali Hend M. Tag Amaal Mohammadein Nahla S. El-Shenawy Mohamed Salah El-Naggar Mercaptophos impacts on redox status biomarkers of common carp (Cyprinus carpio) as an endocrine disruptor
description	Endocrine-disrupting chemicals (EDCs) are compounds that affect the way the endocrine system works in both humans and animals. The emphasis of the research was on the negative effects of mercaptophos exposure on Cyprinus carpio. Fish were subjected to sub-lethal amounts of mercaptophos at low (0.83 ppm) and high (2.1 ppm) concentrations for 12, 24, 48, and 96 h. The levels of lipid peroxidation (LPO), protein carbonyl (PC), and glutathione (GSH) were tested in the fish liver. Plasma cortisol and testosterone levels, as well as a histological examination of liver tissue, were also assessed. C. carpio treated with mercaptophos had lower testosterone levels and higher cortisol levels at all time intervals. Mercaptophos exhibited oxidative stress in C. carpio, which causes a time-and concentration-dependent augmentation of liver LPO and PC levels, which is linked to hepatic GSH depletion. A low concentration of mercaptophos caused atrophy of pancreatic acinar cells as well as the detection of karyolysis nuclei, according to histological alterations in hepatic tissue. Treatment with a high dosage of mercaptophos resulted in hypertrophy of Kupffer cells as well as coagulative necrosis of pancreatic tissue. Furthermore, short-term mercaptophos exposure reduced testosterone and cortisol levels in C. carpio, which are associated with the development of oxidative stress. Changes in hormone levels and oxidative stress markers in C. carpio may therefore aid in the prediction of disease.
format	article
author	Asma W. Al-Thomali Hend M. Tag Amaal Mohammadein Nahla S. El-Shenawy Mohamed Salah El-Naggar
author_facet	Asma W. Al-Thomali Hend M. Tag Amaal Mohammadein Nahla S. El-Shenawy Mohamed Salah El-Naggar
author_sort	Asma W. Al-Thomali
title	Mercaptophos impacts on redox status biomarkers of common carp (Cyprinus carpio) as an endocrine disruptor
title_short	Mercaptophos impacts on redox status biomarkers of common carp (Cyprinus carpio) as an endocrine disruptor
title_full	Mercaptophos impacts on redox status biomarkers of common carp (Cyprinus carpio) as an endocrine disruptor
title_fullStr	Mercaptophos impacts on redox status biomarkers of common carp (Cyprinus carpio) as an endocrine disruptor
title_full_unstemmed	Mercaptophos impacts on redox status biomarkers of common carp (Cyprinus carpio) as an endocrine disruptor
title_sort	mercaptophos impacts on redox status biomarkers of common carp (cyprinus carpio) as an endocrine disruptor
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/8e2824da5f984d148450f293e33c67d0
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Mercaptophos impacts on redox status biomarkers of common carp (Cyprinus carpio) as an endocrine disruptor

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