Genotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study.
The Caribbean ranks seventh among the world regions most affected by cervical cancer. HPV-prevalence and genotype distributions also differ from regions. Knowledge of HPV genotype profiles is important for patients care and HPV vaccination implementation. The objective of this study was to describe...
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oai:doaj.org-article:8e289c1de06b42618a8184299dc22d202021-12-02T20:17:13ZGenotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study.1932-620310.1371/journal.pone.0257915https://doaj.org/article/8e289c1de06b42618a8184299dc22d202021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257915https://doaj.org/toc/1932-6203The Caribbean ranks seventh among the world regions most affected by cervical cancer. HPV-prevalence and genotype distributions also differ from regions. Knowledge of HPV genotype profiles is important for patients care and HPV vaccination implementation. The objective of this study was to describe HPV genotype distribution and risk factors in a population-based cohort of women in Martinique. In this study, 1312 women were included and underwent cervical cancer screening with successful sample collection between 2009 and 2014. Sociodemographic and clinical variables were recorded. Cytological examination of cervical vaginal smear was performed and classified(Bethesda). Detection of HPV DNA was performed with the PapilloCheck© Kit from Greiner Bio-one. Genotypes were analyzed for18 high-risk HPV (hrHPV) and 6low-risk HPV(lrHPV) types. A total of 1075 women were included with a mean age of 49.1±10.5 years. HPV prevalence was 27.6% (297/1075) with 19.4% (209/1075) women with only hrHPV, 5.3% (57/1075) with only lrHPV. Multiple infections (hrHPV/lrHPV) were detected in 31/240 cases of hrHPV (12.9%). A total of 353 hrHPV genotypes were analyzed; the most common HPV types were HPV51 (11.0%), HPV68 (10.8%), HPV53 (9.1%) and HPV 52 (7.1%). HPV16 and HPV18 represented respectively 4.8% and 4.0% of hrHPV genotypes. Abnormal cytology was observed in 34 cases (3.2%), with 14 ASCUS (1.3%), 10 LSIL (0.9%), 5 HSIL (0.5%), 3 ASC-H (0.3%) and 2 AGC (0.2%). Fifteen (44.1%) were hrHPV and 4 (14.7%) lrHPV; 7 cases of hrPHV were in the age-group 25-34 years. Among 1041cases of normal cytology, 225 had positive hrHPV detection (21.6%). This is the first population-based study of HPV profiles in our country, and we found a high prevalence of hrHPV. The most common genotypes were HPV51, 68, 53. These results could serve for cancer vaccination strategies and HPV surveillance in Martinique.Fatiha NajioullahMarie-José DorivalClarisse JoachimChristiane DispagneJonathan MacniSylvie AbelCaroline SulpicyHuguette Charpentier-BaltideDanièle Sainte-RoseBéatrice Salomon-FrechouMoustapha DieyeJacqueline Véronique-BaudinMaurice PréMaurice MarquetGaëlle Wan-AjouhuEustase JankyDidier RiethmullerRaymond CesaireDEPIPAPUFR study groupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0257915 (2021) |
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Medicine R Science Q Fatiha Najioullah Marie-José Dorival Clarisse Joachim Christiane Dispagne Jonathan Macni Sylvie Abel Caroline Sulpicy Huguette Charpentier-Baltide Danièle Sainte-Rose Béatrice Salomon-Frechou Moustapha Dieye Jacqueline Véronique-Baudin Maurice Pré Maurice Marquet Gaëlle Wan-Ajouhu Eustase Janky Didier Riethmuller Raymond Cesaire DEPIPAPUFR study group Genotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study. |
| description |
The Caribbean ranks seventh among the world regions most affected by cervical cancer. HPV-prevalence and genotype distributions also differ from regions. Knowledge of HPV genotype profiles is important for patients care and HPV vaccination implementation. The objective of this study was to describe HPV genotype distribution and risk factors in a population-based cohort of women in Martinique. In this study, 1312 women were included and underwent cervical cancer screening with successful sample collection between 2009 and 2014. Sociodemographic and clinical variables were recorded. Cytological examination of cervical vaginal smear was performed and classified(Bethesda). Detection of HPV DNA was performed with the PapilloCheck© Kit from Greiner Bio-one. Genotypes were analyzed for18 high-risk HPV (hrHPV) and 6low-risk HPV(lrHPV) types. A total of 1075 women were included with a mean age of 49.1±10.5 years. HPV prevalence was 27.6% (297/1075) with 19.4% (209/1075) women with only hrHPV, 5.3% (57/1075) with only lrHPV. Multiple infections (hrHPV/lrHPV) were detected in 31/240 cases of hrHPV (12.9%). A total of 353 hrHPV genotypes were analyzed; the most common HPV types were HPV51 (11.0%), HPV68 (10.8%), HPV53 (9.1%) and HPV 52 (7.1%). HPV16 and HPV18 represented respectively 4.8% and 4.0% of hrHPV genotypes. Abnormal cytology was observed in 34 cases (3.2%), with 14 ASCUS (1.3%), 10 LSIL (0.9%), 5 HSIL (0.5%), 3 ASC-H (0.3%) and 2 AGC (0.2%). Fifteen (44.1%) were hrHPV and 4 (14.7%) lrHPV; 7 cases of hrPHV were in the age-group 25-34 years. Among 1041cases of normal cytology, 225 had positive hrHPV detection (21.6%). This is the first population-based study of HPV profiles in our country, and we found a high prevalence of hrHPV. The most common genotypes were HPV51, 68, 53. These results could serve for cancer vaccination strategies and HPV surveillance in Martinique. |
| format |
article |
| author |
Fatiha Najioullah Marie-José Dorival Clarisse Joachim Christiane Dispagne Jonathan Macni Sylvie Abel Caroline Sulpicy Huguette Charpentier-Baltide Danièle Sainte-Rose Béatrice Salomon-Frechou Moustapha Dieye Jacqueline Véronique-Baudin Maurice Pré Maurice Marquet Gaëlle Wan-Ajouhu Eustase Janky Didier Riethmuller Raymond Cesaire DEPIPAPUFR study group |
| author_facet |
Fatiha Najioullah Marie-José Dorival Clarisse Joachim Christiane Dispagne Jonathan Macni Sylvie Abel Caroline Sulpicy Huguette Charpentier-Baltide Danièle Sainte-Rose Béatrice Salomon-Frechou Moustapha Dieye Jacqueline Véronique-Baudin Maurice Pré Maurice Marquet Gaëlle Wan-Ajouhu Eustase Janky Didier Riethmuller Raymond Cesaire DEPIPAPUFR study group |
| author_sort |
Fatiha Najioullah |
| title |
Genotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study. |
| title_short |
Genotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study. |
| title_full |
Genotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study. |
| title_fullStr |
Genotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study. |
| title_full_unstemmed |
Genotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study. |
| title_sort |
genotype distribution of cervical hpv among caribbean women in a population-based study in martinique: the depipapufr study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/8e289c1de06b42618a8184299dc22d20 |
| work_keys_str_mv |
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