Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch

JMJD1A is essential for thermogenic gene induction in brown adipose tissue. Here the authors show that white adipose tissue beige-ing requires both β-adrenergic-dependent phosphorylation of S265 and demethylation activity of JMJD1A while brown adipose tissue-driven thermogenesis requires β-adrenergi...

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Autores principales:	Yohei Abe, Yosuke Fujiwara, Hiroki Takahashi, Yoshihiro Matsumura, Tomonobu Sawada, Shuying Jiang, Ryo Nakaki, Aoi Uchida, Noriko Nagao, Makoto Naito, Shingo Kajimura, Hiroshi Kimura, Timothy F. Osborne, Hiroyuki Aburatani, Tatsuhiko Kodama, Takeshi Inagaki, Juro Sakai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e2974ccca4346e5a092dfe5a533855a
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spelling	oai:doaj.org-article:8e2974ccca4346e5a092dfe5a533855a2021-12-02T16:49:32ZHistone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch10.1038/s41467-018-03868-82041-1723https://doaj.org/article/8e2974ccca4346e5a092dfe5a533855a2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03868-8https://doaj.org/toc/2041-1723JMJD1A is essential for thermogenic gene induction in brown adipose tissue. Here the authors show that white adipose tissue beige-ing requires both β-adrenergic-dependent phosphorylation of S265 and demethylation activity of JMJD1A while brown adipose tissue-driven thermogenesis requires β-adrenergic dependent phosphorylation of S265 but is independent of H3K9me2 demethylation.Yohei AbeYosuke FujiwaraHiroki TakahashiYoshihiro MatsumuraTomonobu SawadaShuying JiangRyo NakakiAoi UchidaNoriko NagaoMakoto NaitoShingo KajimuraHiroshi KimuraTimothy F. OsborneHiroyuki AburataniTatsuhiko KodamaTakeshi InagakiJuro SakaiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yohei Abe Yosuke Fujiwara Hiroki Takahashi Yoshihiro Matsumura Tomonobu Sawada Shuying Jiang Ryo Nakaki Aoi Uchida Noriko Nagao Makoto Naito Shingo Kajimura Hiroshi Kimura Timothy F. Osborne Hiroyuki Aburatani Tatsuhiko Kodama Takeshi Inagaki Juro Sakai Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch
description	JMJD1A is essential for thermogenic gene induction in brown adipose tissue. Here the authors show that white adipose tissue beige-ing requires both β-adrenergic-dependent phosphorylation of S265 and demethylation activity of JMJD1A while brown adipose tissue-driven thermogenesis requires β-adrenergic dependent phosphorylation of S265 but is independent of H3K9me2 demethylation.
format	article
author	Yohei Abe Yosuke Fujiwara Hiroki Takahashi Yoshihiro Matsumura Tomonobu Sawada Shuying Jiang Ryo Nakaki Aoi Uchida Noriko Nagao Makoto Naito Shingo Kajimura Hiroshi Kimura Timothy F. Osborne Hiroyuki Aburatani Tatsuhiko Kodama Takeshi Inagaki Juro Sakai
author_facet	Yohei Abe Yosuke Fujiwara Hiroki Takahashi Yoshihiro Matsumura Tomonobu Sawada Shuying Jiang Ryo Nakaki Aoi Uchida Noriko Nagao Makoto Naito Shingo Kajimura Hiroshi Kimura Timothy F. Osborne Hiroyuki Aburatani Tatsuhiko Kodama Takeshi Inagaki Juro Sakai
author_sort	Yohei Abe
title	Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch
title_short	Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch
title_full	Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch
title_fullStr	Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch
title_full_unstemmed	Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch
title_sort	histone demethylase jmjd1a coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8e2974ccca4346e5a092dfe5a533855a
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Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch

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