Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
Abstract The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional status and survival. The underlying causes of cachexia are incompletely...
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Nature Portfolio
2017
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oai:doaj.org-article:8e2fd60ce44a48aa9b84c81781b5c0b32021-12-02T16:08:10ZCancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling10.1038/s41598-017-02088-22045-2322https://doaj.org/article/8e2fd60ce44a48aa9b84c81781b5c0b32017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02088-2https://doaj.org/toc/2045-2322Abstract The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional status and survival. The underlying causes of cachexia are incompletely understood, and currently no therapeutic approach can completely reverse the condition. Autophagy coordinates lysosomal destruction of cytosolic constituents and is systemically induced by starvation. We hypothesized that starvation-mimicking signaling compounds secreted from tumor cells may cause a systemic acceleration of autophagy during cachexia. We found that IL-6 secreted by tumor cells accelerates autophagy in myotubes when complexed with soluble IL-6 receptor (trans-signaling). In lung cancer patients, were cachexia is prevalent, there was a significant correlation between elevated IL-6 expression in the tumor and poor prognosis of the patients. We found evidence for an autophagy-inducing bioactivity in serum from cancer patients and that this is clearly associated with weight loss. Importantly, the autophagy-inducing bioactivity was reduced by interference with IL-6 trans-signaling. Together, our findings suggest that IL-6 trans-signaling may be targeted in cancer cachexia.Kristine PettersenSonja AndersenSimone DegenValentina TadiniJoël GrosjeanShinji HatakeyamaAlmaz N. TesfahunSiver MoestueJana KimUnni NonstadPål R. RomundstadFrank SkorpenSveinung SørhaugTore AmundsenBjørn H. GrønbergFlorian StrasserNathan StephensDag HoemAnders MolvenStein KaasaKenneth FearonCarsten JacobiGeir BjørkøyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017) |
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Medicine R Science Q |
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Medicine R Science Q Kristine Pettersen Sonja Andersen Simone Degen Valentina Tadini Joël Grosjean Shinji Hatakeyama Almaz N. Tesfahun Siver Moestue Jana Kim Unni Nonstad Pål R. Romundstad Frank Skorpen Sveinung Sørhaug Tore Amundsen Bjørn H. Grønberg Florian Strasser Nathan Stephens Dag Hoem Anders Molven Stein Kaasa Kenneth Fearon Carsten Jacobi Geir Bjørkøy Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling |
| description |
Abstract The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional status and survival. The underlying causes of cachexia are incompletely understood, and currently no therapeutic approach can completely reverse the condition. Autophagy coordinates lysosomal destruction of cytosolic constituents and is systemically induced by starvation. We hypothesized that starvation-mimicking signaling compounds secreted from tumor cells may cause a systemic acceleration of autophagy during cachexia. We found that IL-6 secreted by tumor cells accelerates autophagy in myotubes when complexed with soluble IL-6 receptor (trans-signaling). In lung cancer patients, were cachexia is prevalent, there was a significant correlation between elevated IL-6 expression in the tumor and poor prognosis of the patients. We found evidence for an autophagy-inducing bioactivity in serum from cancer patients and that this is clearly associated with weight loss. Importantly, the autophagy-inducing bioactivity was reduced by interference with IL-6 trans-signaling. Together, our findings suggest that IL-6 trans-signaling may be targeted in cancer cachexia. |
| format |
article |
| author |
Kristine Pettersen Sonja Andersen Simone Degen Valentina Tadini Joël Grosjean Shinji Hatakeyama Almaz N. Tesfahun Siver Moestue Jana Kim Unni Nonstad Pål R. Romundstad Frank Skorpen Sveinung Sørhaug Tore Amundsen Bjørn H. Grønberg Florian Strasser Nathan Stephens Dag Hoem Anders Molven Stein Kaasa Kenneth Fearon Carsten Jacobi Geir Bjørkøy |
| author_facet |
Kristine Pettersen Sonja Andersen Simone Degen Valentina Tadini Joël Grosjean Shinji Hatakeyama Almaz N. Tesfahun Siver Moestue Jana Kim Unni Nonstad Pål R. Romundstad Frank Skorpen Sveinung Sørhaug Tore Amundsen Bjørn H. Grønberg Florian Strasser Nathan Stephens Dag Hoem Anders Molven Stein Kaasa Kenneth Fearon Carsten Jacobi Geir Bjørkøy |
| author_sort |
Kristine Pettersen |
| title |
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling |
| title_short |
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling |
| title_full |
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling |
| title_fullStr |
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling |
| title_full_unstemmed |
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling |
| title_sort |
cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived il-6 trans-signaling |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/8e2fd60ce44a48aa9b84c81781b5c0b3 |
| work_keys_str_mv |
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| _version_ |
1718384610015969280 |