CYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST ACTIVATED CD4+ AND CD8+T-LYMPHOCYTES IN THE CULTURE IN VITRO

The aim of the present study was a comparative assessment of the cytotoxic activity of IFNα-induced dendritic cells (IFN-DCs) and IL-4-induced DCs (IL4-DCs) against allo-MLC- activated CD4+ and CD8+T-lymphocytes. It was shown the level of AnnexinV+/PI- cells corresponding to early apoptosis among CD...

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Autores principales:	T. V. Tyrinova, O. Yu. Leplina, M. A. Tihonova, A. A. Ostanin, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	cd4+t-лимфоциты cd8+t-лимфоциты dendritic cells cd4+ t-lymphocytes cd8+t-lymphocytes apoptosis Science Q
Acceso en línea:	https://doaj.org/article/8e305e39cedc4b10beed1c6728f6f33a
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spelling	oai:doaj.org-article:8e305e39cedc4b10beed1c6728f6f33a2021-11-23T06:14:20ZCYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST ACTIVATED CD4+ AND CD8+T-LYMPHOCYTES IN THE CULTURE IN VITRO2541-94202587-9596https://doaj.org/article/8e305e39cedc4b10beed1c6728f6f33a2012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/946https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The aim of the present study was a comparative assessment of the cytotoxic activity of IFNα-induced dendritic cells (IFN-DCs) and IL-4-induced DCs (IL4-DCs) against allo-MLC- activated CD4+ and CD8+T-lymphocytes. It was shown the level of AnnexinV+/PI- cells corresponding to early apoptosis among CD4+T-lymphocytes was lower in cultures with IFN-DCs compared with IL4-DCs. At the same time the relative number of AnnexinV+/ PI+ cells (late phase of apoptosis/necrosis) among CD4+T-lymphocytes activated by allogenic IFN-DCs and IL4-DCs increased in an equal degree. It was demonstrated that IFN-DCs possesed similar ability to induce apoptosis of CD3+CD8+T-lymphocytes.T. V. TyrinovaO. Yu. LeplinaM. A. TihonovaA. A. OstaninE. R. ChernykhScientific Сentre for Family Health and Human Reproduction Problemsarticlecd4+t-лимфоцитыcd8+t-лимфоцитыdendritic cellscd4+ t-lymphocytescd8+t-lymphocytesapoptosisScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 327-331 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	cd4+t-лимфоциты cd8+t-лимфоциты dendritic cells cd4+ t-lymphocytes cd8+t-lymphocytes apoptosis Science Q
spellingShingle	cd4+t-лимфоциты cd8+t-лимфоциты dendritic cells cd4+ t-lymphocytes cd8+t-lymphocytes apoptosis Science Q T. V. Tyrinova O. Yu. Leplina M. A. Tihonova A. A. Ostanin E. R. Chernykh CYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST ACTIVATED CD4+ AND CD8+T-LYMPHOCYTES IN THE CULTURE IN VITRO
description	The aim of the present study was a comparative assessment of the cytotoxic activity of IFNα-induced dendritic cells (IFN-DCs) and IL-4-induced DCs (IL4-DCs) against allo-MLC- activated CD4+ and CD8+T-lymphocytes. It was shown the level of AnnexinV+/PI- cells corresponding to early apoptosis among CD4+T-lymphocytes was lower in cultures with IFN-DCs compared with IL4-DCs. At the same time the relative number of AnnexinV+/ PI+ cells (late phase of apoptosis/necrosis) among CD4+T-lymphocytes activated by allogenic IFN-DCs and IL4-DCs increased in an equal degree. It was demonstrated that IFN-DCs possesed similar ability to induce apoptosis of CD3+CD8+T-lymphocytes.
format	article
author	T. V. Tyrinova O. Yu. Leplina M. A. Tihonova A. A. Ostanin E. R. Chernykh
author_facet	T. V. Tyrinova O. Yu. Leplina M. A. Tihonova A. A. Ostanin E. R. Chernykh
author_sort	T. V. Tyrinova
title	CYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST ACTIVATED CD4+ AND CD8+T-LYMPHOCYTES IN THE CULTURE IN VITRO
title_short	CYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST ACTIVATED CD4+ AND CD8+T-LYMPHOCYTES IN THE CULTURE IN VITRO
title_full	CYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST ACTIVATED CD4+ AND CD8+T-LYMPHOCYTES IN THE CULTURE IN VITRO
title_fullStr	CYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST ACTIVATED CD4+ AND CD8+T-LYMPHOCYTES IN THE CULTURE IN VITRO
title_full_unstemmed	CYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST ACTIVATED CD4+ AND CD8+T-LYMPHOCYTES IN THE CULTURE IN VITRO
title_sort	cytotoxic activity of dendritic cells against activated cd4+ and cd8+t-lymphocytes in the culture in vitro
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/8e305e39cedc4b10beed1c6728f6f33a
work_keys_str_mv	AT tvtyrinova cytotoxicactivityofdendriticcellsagainstactivatedcd4andcd8tlymphocytesinthecultureinvitro AT oyuleplina cytotoxicactivityofdendriticcellsagainstactivatedcd4andcd8tlymphocytesinthecultureinvitro AT matihonova cytotoxicactivityofdendriticcellsagainstactivatedcd4andcd8tlymphocytesinthecultureinvitro AT aaostanin cytotoxicactivityofdendriticcellsagainstactivatedcd4andcd8tlymphocytesinthecultureinvitro AT erchernykh cytotoxicactivityofdendriticcellsagainstactivatedcd4andcd8tlymphocytesinthecultureinvitro
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CYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST ACTIVATED CD4+ AND CD8+T-LYMPHOCYTES IN THE CULTURE IN VITRO

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