Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis

Slug supports heart development and tumor metastasis, but its role in blood vessel formation is less clear. Here the authors show that endothelial cell-expressed Slug regulates both physiologic and pathological angiogenesis, at least in part through the modulation of Notch signalling.

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Autores principales:	Nan W. Hultgren, Jennifer S. Fang, Mary E. Ziegler, Ricardo N. Ramirez, Duc T. T. Phan, Michaela M. S. Hatch, Katrina M. Welch-Reardon, Antonio E. Paniagua, Lin S. Kim, Nathan N. Shon, David S. Williams, Ali Mortazavi, Christopher C. W. Hughes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e37d57515834f55b45498858d31ca32
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spelling	oai:doaj.org-article:8e37d57515834f55b45498858d31ca322021-12-02T16:49:27ZSlug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis10.1038/s41467-020-18633-z2041-1723https://doaj.org/article/8e37d57515834f55b45498858d31ca322020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18633-zhttps://doaj.org/toc/2041-1723Slug supports heart development and tumor metastasis, but its role in blood vessel formation is less clear. Here the authors show that endothelial cell-expressed Slug regulates both physiologic and pathological angiogenesis, at least in part through the modulation of Notch signalling.Nan W. HultgrenJennifer S. FangMary E. ZieglerRicardo N. RamirezDuc T. T. PhanMichaela M. S. HatchKatrina M. Welch-ReardonAntonio E. PaniaguaLin S. KimNathan N. ShonDavid S. WilliamsAli MortazaviChristopher C. W. HughesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nan W. Hultgren Jennifer S. Fang Mary E. Ziegler Ricardo N. Ramirez Duc T. T. Phan Michaela M. S. Hatch Katrina M. Welch-Reardon Antonio E. Paniagua Lin S. Kim Nathan N. Shon David S. Williams Ali Mortazavi Christopher C. W. Hughes Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis
description	Slug supports heart development and tumor metastasis, but its role in blood vessel formation is less clear. Here the authors show that endothelial cell-expressed Slug regulates both physiologic and pathological angiogenesis, at least in part through the modulation of Notch signalling.
format	article
author	Nan W. Hultgren Jennifer S. Fang Mary E. Ziegler Ricardo N. Ramirez Duc T. T. Phan Michaela M. S. Hatch Katrina M. Welch-Reardon Antonio E. Paniagua Lin S. Kim Nathan N. Shon David S. Williams Ali Mortazavi Christopher C. W. Hughes
author_facet	Nan W. Hultgren Jennifer S. Fang Mary E. Ziegler Ricardo N. Ramirez Duc T. T. Phan Michaela M. S. Hatch Katrina M. Welch-Reardon Antonio E. Paniagua Lin S. Kim Nathan N. Shon David S. Williams Ali Mortazavi Christopher C. W. Hughes
author_sort	Nan W. Hultgren
title	Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis
title_short	Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis
title_full	Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis
title_fullStr	Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis
title_full_unstemmed	Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis
title_sort	slug regulates the dll4-notch-vegfr2 axis to control endothelial cell activation and angiogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8e37d57515834f55b45498858d31ca32
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Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis

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