Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts

Qiuting Mo, 1, 2 Hao Fu, 1, 2 Dan Zhao, 1– 3 Jiachan Zhang, 1– 3 Changtao Wang, 1– 3 Dongdong Wang, 1, 2 Meng Li 1, 2 1Beijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business Uni...

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Autores principales:	Mo Q, Fu H, Zhao D, Zhang J, Wang C, Wang D, Li M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	siraitia grosvenorii mogroside v oxidative stress antioxidant Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8e39747dd1a54a349c03d8db3f224f18
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spelling	oai:doaj.org-article:8e39747dd1a54a349c03d8db3f224f182021-12-02T19:17:36ZProtective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts1177-8881https://doaj.org/article/8e39747dd1a54a349c03d8db3f224f182021-12-01T00:00:00Zhttps://www.dovepress.com/protective-effects-of-mogroside-v-on-oxidative-stress-induced-by-h2o2--peer-reviewed-fulltext-article-DDDThttps://doaj.org/toc/1177-8881Qiuting Mo, 1, 2 Hao Fu, 1, 2 Dan Zhao, 1– 3 Jiachan Zhang, 1– 3 Changtao Wang, 1– 3 Dongdong Wang, 1, 2 Meng Li 1, 2 1Beijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, People’s Republic of China; 2Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People’s Republic of China; 3Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, People’s Republic of ChinaCorrespondence: Dongdong Wang; Meng Li Tel/Fax +86-010-68984917Email Wdd@btbu.edu.cn; limeng@btbu.edu.cnPurpose: Damage caused by oxidative stress leads to the premature aging of cells. Mogrosides, the main active components of Siraitia grosvenorii, have strong antioxidant activity; however, it is unclear whether mogroside V (MV) exerts these effects in skin cells. This was investigated in the present study by evaluating the protective effects of MV against oxidative damage induced by hydrogen peroxide (H 2O 2) in skin fibroblasts.Methods: Mouse skin fibroblasts (MSFs) were treated with H 2O 2 and cell viability, total antioxidant capacity, reactive oxygen species (ROS) production, malondialdehyde (MDA) content, and antioxidant enzyme activity were assessed.Results: Treatment with MV reduced the ROS level and MDA content in MSFs treated with H 2O 2. This was accompanied by increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities.Conclusion: MV reduces H 2O 2-induced oxidative stress and enhances endogenous antioxidant activity in skin fibroblasts. Thus, MV can potentially be used as an ingredient in anti-aging cosmetic products.Keywords: Siraitia grosvenorii, mogroside V, oxidative stress, antioxidantMo QFu HZhao DZhang JWang CWang DLi MDove Medical Pressarticlesiraitia grosvenoriimogroside voxidative stressantioxidantTherapeutics. PharmacologyRM1-950ENDrug Design, Development and Therapy, Vol Volume 15, Pp 4901-4909 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	siraitia grosvenorii mogroside v oxidative stress antioxidant Therapeutics. Pharmacology RM1-950
spellingShingle	siraitia grosvenorii mogroside v oxidative stress antioxidant Therapeutics. Pharmacology RM1-950 Mo Q Fu H Zhao D Zhang J Wang C Wang D Li M Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts
description	Qiuting Mo, 1, 2 Hao Fu, 1, 2 Dan Zhao, 1– 3 Jiachan Zhang, 1– 3 Changtao Wang, 1– 3 Dongdong Wang, 1, 2 Meng Li 1, 2 1Beijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, People’s Republic of China; 2Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People’s Republic of China; 3Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, People’s Republic of ChinaCorrespondence: Dongdong Wang; Meng Li Tel/Fax +86-010-68984917Email Wdd@btbu.edu.cn; limeng@btbu.edu.cnPurpose: Damage caused by oxidative stress leads to the premature aging of cells. Mogrosides, the main active components of Siraitia grosvenorii, have strong antioxidant activity; however, it is unclear whether mogroside V (MV) exerts these effects in skin cells. This was investigated in the present study by evaluating the protective effects of MV against oxidative damage induced by hydrogen peroxide (H 2O 2) in skin fibroblasts.Methods: Mouse skin fibroblasts (MSFs) were treated with H 2O 2 and cell viability, total antioxidant capacity, reactive oxygen species (ROS) production, malondialdehyde (MDA) content, and antioxidant enzyme activity were assessed.Results: Treatment with MV reduced the ROS level and MDA content in MSFs treated with H 2O 2. This was accompanied by increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities.Conclusion: MV reduces H 2O 2-induced oxidative stress and enhances endogenous antioxidant activity in skin fibroblasts. Thus, MV can potentially be used as an ingredient in anti-aging cosmetic products.Keywords: Siraitia grosvenorii, mogroside V, oxidative stress, antioxidant
format	article
author	Mo Q Fu H Zhao D Zhang J Wang C Wang D Li M
author_facet	Mo Q Fu H Zhao D Zhang J Wang C Wang D Li M
author_sort	Mo Q
title	Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts
title_short	Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts
title_full	Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts
title_fullStr	Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts
title_full_unstemmed	Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts
title_sort	protective effects of mogroside v on oxidative stress induced by h2o2 in skin fibroblasts
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8e39747dd1a54a349c03d8db3f224f18
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Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts

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