Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis

Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis

Obesity is associated with altered N-acylethanolamine levels (NAE). Here the authors show that deletion of the gene encoding N-acylphosphatidylethanolamine phospholipase D, a key enzyme for NAE synthesis, in intestinal cells of mice leads to the development of obesity and hepatic steatosis via a mec...

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Main Authors: Amandine Everard, Hubert Plovier, Marialetizia Rastelli, Matthias Van Hul, Alice de Wouters d’Oplinter, Lucie Geurts, Céline Druart, Sylvie Robine, Nathalie M. Delzenne, Giulio G. Muccioli, Willem M. de Vos, Serge Luquet, Nicolas Flamand, Vincenzo Di Marzo, Patrice D. Cani
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/8e39baa76b0c434ca412a8f048d3869a
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Summary:Obesity is associated with altered N-acylethanolamine levels (NAE). Here the authors show that deletion of the gene encoding N-acylphosphatidylethanolamine phospholipase D, a key enzyme for NAE synthesis, in intestinal cells of mice leads to the development of obesity and hepatic steatosis via a mechanism involving the gut-brain axis.

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