Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis

Obesity is associated with altered N-acylethanolamine levels (NAE). Here the authors show that deletion of the gene encoding N-acylphosphatidylethanolamine phospholipase D, a key enzyme for NAE synthesis, in intestinal cells of mice leads to the development of obesity and hepatic steatosis via a mec...

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Autores principales:	Amandine Everard, Hubert Plovier, Marialetizia Rastelli, Matthias Van Hul, Alice de Wouters d’Oplinter, Lucie Geurts, Céline Druart, Sylvie Robine, Nathalie M. Delzenne, Giulio G. Muccioli, Willem M. de Vos, Serge Luquet, Nicolas Flamand, Vincenzo Di Marzo, Patrice D. Cani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e39baa76b0c434ca412a8f048d3869a
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spelling	oai:doaj.org-article:8e39baa76b0c434ca412a8f048d3869a2021-12-02T16:58:26ZIntestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis10.1038/s41467-018-08051-72041-1723https://doaj.org/article/8e39baa76b0c434ca412a8f048d3869a2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08051-7https://doaj.org/toc/2041-1723Obesity is associated with altered N-acylethanolamine levels (NAE). Here the authors show that deletion of the gene encoding N-acylphosphatidylethanolamine phospholipase D, a key enzyme for NAE synthesis, in intestinal cells of mice leads to the development of obesity and hepatic steatosis via a mechanism involving the gut-brain axis.Amandine EverardHubert PlovierMarialetizia RastelliMatthias Van HulAlice de Wouters d’OplinterLucie GeurtsCéline DruartSylvie RobineNathalie M. DelzenneGiulio G. MuccioliWillem M. de VosSerge LuquetNicolas FlamandVincenzo Di MarzoPatrice D. CaniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amandine Everard Hubert Plovier Marialetizia Rastelli Matthias Van Hul Alice de Wouters d’Oplinter Lucie Geurts Céline Druart Sylvie Robine Nathalie M. Delzenne Giulio G. Muccioli Willem M. de Vos Serge Luquet Nicolas Flamand Vincenzo Di Marzo Patrice D. Cani Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis
description	Obesity is associated with altered N-acylethanolamine levels (NAE). Here the authors show that deletion of the gene encoding N-acylphosphatidylethanolamine phospholipase D, a key enzyme for NAE synthesis, in intestinal cells of mice leads to the development of obesity and hepatic steatosis via a mechanism involving the gut-brain axis.
format	article
author	Amandine Everard Hubert Plovier Marialetizia Rastelli Matthias Van Hul Alice de Wouters d’Oplinter Lucie Geurts Céline Druart Sylvie Robine Nathalie M. Delzenne Giulio G. Muccioli Willem M. de Vos Serge Luquet Nicolas Flamand Vincenzo Di Marzo Patrice D. Cani
author_facet	Amandine Everard Hubert Plovier Marialetizia Rastelli Matthias Van Hul Alice de Wouters d’Oplinter Lucie Geurts Céline Druart Sylvie Robine Nathalie M. Delzenne Giulio G. Muccioli Willem M. de Vos Serge Luquet Nicolas Flamand Vincenzo Di Marzo Patrice D. Cani
author_sort	Amandine Everard
title	Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis
title_short	Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis
title_full	Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis
title_fullStr	Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis
title_full_unstemmed	Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis
title_sort	intestinal epithelial n-acylphosphatidylethanolamine phospholipase d links dietary fat to metabolic adaptations in obesity and steatosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8e39baa76b0c434ca412a8f048d3869a
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Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis

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