Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38

The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential phosphorylation, thereby modulating ATF2’s sensitivity to...

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Autores principales:	Klára Kirsch, András Zeke, Orsolya Tőke, Péter Sok, Ashish Sethi, Anna Sebő, Ganesan Senthil Kumar, Péter Egri, Ádám L. Póti, Paul Gooley, Wolfgang Peti, Isabel Bento, Anita Alexa, Attila Reményi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e3a384b4b1a49a98424465168b5b1a6
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spelling	oai:doaj.org-article:8e3a384b4b1a49a98424465168b5b1a62021-12-02T15:37:08ZCo-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p3810.1038/s41467-020-19582-32041-1723https://doaj.org/article/8e3a384b4b1a49a98424465168b5b1a62020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19582-3https://doaj.org/toc/2041-1723The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential phosphorylation, thereby modulating ATF2’s sensitivity to the JNK and p38 pathways.Klára KirschAndrás ZekeOrsolya TőkePéter SokAshish SethiAnna SebőGanesan Senthil KumarPéter EgriÁdám L. PótiPaul GooleyWolfgang PetiIsabel BentoAnita AlexaAttila ReményiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Klára Kirsch András Zeke Orsolya Tőke Péter Sok Ashish Sethi Anna Sebő Ganesan Senthil Kumar Péter Egri Ádám L. Póti Paul Gooley Wolfgang Peti Isabel Bento Anita Alexa Attila Reményi Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38
description	The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential phosphorylation, thereby modulating ATF2’s sensitivity to the JNK and p38 pathways.
format	article
author	Klára Kirsch András Zeke Orsolya Tőke Péter Sok Ashish Sethi Anna Sebő Ganesan Senthil Kumar Péter Egri Ádám L. Póti Paul Gooley Wolfgang Peti Isabel Bento Anita Alexa Attila Reményi
author_facet	Klára Kirsch András Zeke Orsolya Tőke Péter Sok Ashish Sethi Anna Sebő Ganesan Senthil Kumar Péter Egri Ádám L. Póti Paul Gooley Wolfgang Peti Isabel Bento Anita Alexa Attila Reményi
author_sort	Klára Kirsch
title	Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38
title_short	Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38
title_full	Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38
title_fullStr	Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38
title_full_unstemmed	Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38
title_sort	co-regulation of the transcription controlling atf2 phosphoswitch by jnk and p38
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8e3a384b4b1a49a98424465168b5b1a6
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Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38

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