Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes

The prognosis of cancer patients with lymph node (LN) metastasis is worse than those without. Here, the authors report that while histone deacetylase 11 (HDAC11) inhibition suppresses tumor growth within the LN, it also promotes cancer cell migration out of the LN to form distant metastasis, and the...

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Autores principales:	Patrick L. Leslie, Yvonne L. Chao, Yi-Hsuan Tsai, Subrata K. Ghosh, Alessandro Porrello, Amanda E. D. Van Swearingen, Emily B. Harrison, Brian C. Cooley, Joel S. Parker, Lisa A. Carey, Chad V. Pecot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e3b52eb05f3442ca4bd8694e416db75
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spelling	oai:doaj.org-article:8e3b52eb05f3442ca4bd8694e416db752021-12-02T16:58:28ZHistone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes10.1038/s41467-019-12222-52041-1723https://doaj.org/article/8e3b52eb05f3442ca4bd8694e416db752019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12222-5https://doaj.org/toc/2041-1723The prognosis of cancer patients with lymph node (LN) metastasis is worse than those without. Here, the authors report that while histone deacetylase 11 (HDAC11) inhibition suppresses tumor growth within the LN, it also promotes cancer cell migration out of the LN to form distant metastasis, and therefore suggest caution with HDAC inhibitors.Patrick L. LeslieYvonne L. ChaoYi-Hsuan TsaiSubrata K. GhoshAlessandro PorrelloAmanda E. D. Van SwearingenEmily B. HarrisonBrian C. CooleyJoel S. ParkerLisa A. CareyChad V. PecotNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patrick L. Leslie Yvonne L. Chao Yi-Hsuan Tsai Subrata K. Ghosh Alessandro Porrello Amanda E. D. Van Swearingen Emily B. Harrison Brian C. Cooley Joel S. Parker Lisa A. Carey Chad V. Pecot Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes
description	The prognosis of cancer patients with lymph node (LN) metastasis is worse than those without. Here, the authors report that while histone deacetylase 11 (HDAC11) inhibition suppresses tumor growth within the LN, it also promotes cancer cell migration out of the LN to form distant metastasis, and therefore suggest caution with HDAC inhibitors.
format	article
author	Patrick L. Leslie Yvonne L. Chao Yi-Hsuan Tsai Subrata K. Ghosh Alessandro Porrello Amanda E. D. Van Swearingen Emily B. Harrison Brian C. Cooley Joel S. Parker Lisa A. Carey Chad V. Pecot
author_facet	Patrick L. Leslie Yvonne L. Chao Yi-Hsuan Tsai Subrata K. Ghosh Alessandro Porrello Amanda E. D. Van Swearingen Emily B. Harrison Brian C. Cooley Joel S. Parker Lisa A. Carey Chad V. Pecot
author_sort	Patrick L. Leslie
title	Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes
title_short	Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes
title_full	Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes
title_fullStr	Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes
title_full_unstemmed	Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes
title_sort	histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8e3b52eb05f3442ca4bd8694e416db75
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Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes

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