High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice

Repeated head impact exposure can cause memory and behavioural impairments but the physiological changes in the brain are not well understood. Here, the authors reveal synaptic adaptations as a potential mechanism for early abnormal behavioural events observed after mild and high-frequency head impa...

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Autores principales:	Stephanie S. Sloley, Bevan S. Main, Charisse N. Winston, Alex C. Harvey, Alice Kaganovich, Holly T. Korthas, Adam P. Caccavano, David N. Zapple, Jian-young Wu, John G. Partridge, Mark R. Cookson, Stefano Vicini, Mark P. Burns
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e3cddd729eb493188315a1ff611d883
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spelling	oai:doaj.org-article:8e3cddd729eb493188315a1ff611d8832021-12-02T16:57:56ZHigh-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice10.1038/s41467-021-22744-62041-1723https://doaj.org/article/8e3cddd729eb493188315a1ff611d8832021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22744-6https://doaj.org/toc/2041-1723Repeated head impact exposure can cause memory and behavioural impairments but the physiological changes in the brain are not well understood. Here, the authors reveal synaptic adaptations as a potential mechanism for early abnormal behavioural events observed after mild and high-frequency head impact.Stephanie S. SloleyBevan S. MainCharisse N. WinstonAlex C. HarveyAlice KaganovichHolly T. KorthasAdam P. CaccavanoDavid N. ZappleJian-young WuJohn G. PartridgeMark R. CooksonStefano ViciniMark P. BurnsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephanie S. Sloley Bevan S. Main Charisse N. Winston Alex C. Harvey Alice Kaganovich Holly T. Korthas Adam P. Caccavano David N. Zapple Jian-young Wu John G. Partridge Mark R. Cookson Stefano Vicini Mark P. Burns High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice
description	Repeated head impact exposure can cause memory and behavioural impairments but the physiological changes in the brain are not well understood. Here, the authors reveal synaptic adaptations as a potential mechanism for early abnormal behavioural events observed after mild and high-frequency head impact.
format	article
author	Stephanie S. Sloley Bevan S. Main Charisse N. Winston Alex C. Harvey Alice Kaganovich Holly T. Korthas Adam P. Caccavano David N. Zapple Jian-young Wu John G. Partridge Mark R. Cookson Stefano Vicini Mark P. Burns
author_facet	Stephanie S. Sloley Bevan S. Main Charisse N. Winston Alex C. Harvey Alice Kaganovich Holly T. Korthas Adam P. Caccavano David N. Zapple Jian-young Wu John G. Partridge Mark R. Cookson Stefano Vicini Mark P. Burns
author_sort	Stephanie S. Sloley
title	High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice
title_short	High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice
title_full	High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice
title_fullStr	High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice
title_full_unstemmed	High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice
title_sort	high-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8e3cddd729eb493188315a1ff611d883
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High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice

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