Efficiency of Human Plague Vaccination in Tuvinian Natural Plague Focus

Background. Plague is an especially dangerous natural focal infectious disease belonging to a group of quarantine infections. There are eleven natural plague foci in Russian Federation. In Republic Tyva plague endemic territories include Ovyur, Mongun-Taigin and Tes-Hem areas where Y. pestis strains...

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Autores principales:	K. M. Korytov, V. V. Voitkova, V. I. Dubrovina, A. B. Pyatidesyatnikova, A. K. Noskov, E. A. Glushkov, I. S. Akimova, N. V. Ondar, L. K. Salchak, O. S. Mongush, A. D. Dazhikay, A. A. Saydy, Yu. K. Orteney, S. V. Balakhonov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	plague natural focus vaccination blood immunoglobulin cytokine immunophenotyping Science Q
Acceso en línea:	https://doaj.org/article/8e413b6a2ebf4ac9861630dc9ba57141
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spelling	oai:doaj.org-article:8e413b6a2ebf4ac9861630dc9ba571412021-11-23T06:14:43ZEfficiency of Human Plague Vaccination in Tuvinian Natural Plague Focus2541-94202587-959610.29413/ABS.2019-4.5.5https://doaj.org/article/8e413b6a2ebf4ac9861630dc9ba571412019-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2165https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Plague is an especially dangerous natural focal infectious disease belonging to a group of quarantine infections. There are eleven natural plague foci in Russian Federation. In Republic Tyva plague endemic territories include Ovyur, Mongun-Taigin and Tes-Hem areas where Y. pestis strains are intermittently isolated from Citellus undulates. Population living at the territory of the natural foci get immunoprophylaxis against plague at complication of epizootic and epidemic conditions.This paper presents the results of monitoring indicators of the immune status of people vaccinated with the plague vaccine living in the territory of the Tuva natural focus.Materials and methods. The study involved 76 volunteers who had not previously been vaccinated. The study included the determination of production IFN-γ, IL-4, TNF-α by blood cells, titers of specific IgG antibodies to the capsule F1 antigen of the Yersinia pestis, and concentrations of immunoglobulins in serum blood, as well as immunophenotyping of blood lymphocytes.Results. In the course of a comprehensive immunological study, features of the development of cellular and humoral reactions in people living in the territory of the Tuva natural plague focus were established in the first months after vaccination. Changes in the concentration dynamics of the main classes of immunoglobulins were accompanied by an increase in the level of specific IgGs to the F1 within 6 months after immunization. In the same period, a significant increase in the production of cytokines, as well as significant changes in terms of the subpopulation composition of the vaccinated blood.Conclusion. It is necessary to note the importance of studying of the human immune status in 1–3 months after plague vaccination as this period coincides with potentially dangerous season from epidemiological point of view. Nevertheless, much important role for improvement of tactics of the specific prevention measures plays the data received after the revaccination.K. M. KorytovV. V. VoitkovaV. I. DubrovinaA. B. PyatidesyatnikovaA. K. NoskovE. A. GlushkovI. S. AkimovaN. V. OndarL. K. SalchakO. S. MongushA. D. DazhikayA. A. SaydyYu. K. OrteneyS. V. BalakhonovScientific Сentre for Family Health and Human Reproduction Problemsarticleplaguenatural focusvaccinationbloodimmunoglobulincytokineimmunophenotypingScienceQRUActa Biomedica Scientifica, Vol 4, Iss 5, Pp 31-37 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	plague natural focus vaccination blood immunoglobulin cytokine immunophenotyping Science Q
spellingShingle	plague natural focus vaccination blood immunoglobulin cytokine immunophenotyping Science Q K. M. Korytov V. V. Voitkova V. I. Dubrovina A. B. Pyatidesyatnikova A. K. Noskov E. A. Glushkov I. S. Akimova N. V. Ondar L. K. Salchak O. S. Mongush A. D. Dazhikay A. A. Saydy Yu. K. Orteney S. V. Balakhonov Efficiency of Human Plague Vaccination in Tuvinian Natural Plague Focus
description	Background. Plague is an especially dangerous natural focal infectious disease belonging to a group of quarantine infections. There are eleven natural plague foci in Russian Federation. In Republic Tyva plague endemic territories include Ovyur, Mongun-Taigin and Tes-Hem areas where Y. pestis strains are intermittently isolated from Citellus undulates. Population living at the territory of the natural foci get immunoprophylaxis against plague at complication of epizootic and epidemic conditions.This paper presents the results of monitoring indicators of the immune status of people vaccinated with the plague vaccine living in the territory of the Tuva natural focus.Materials and methods. The study involved 76 volunteers who had not previously been vaccinated. The study included the determination of production IFN-γ, IL-4, TNF-α by blood cells, titers of specific IgG antibodies to the capsule F1 antigen of the Yersinia pestis, and concentrations of immunoglobulins in serum blood, as well as immunophenotyping of blood lymphocytes.Results. In the course of a comprehensive immunological study, features of the development of cellular and humoral reactions in people living in the territory of the Tuva natural plague focus were established in the first months after vaccination. Changes in the concentration dynamics of the main classes of immunoglobulins were accompanied by an increase in the level of specific IgGs to the F1 within 6 months after immunization. In the same period, a significant increase in the production of cytokines, as well as significant changes in terms of the subpopulation composition of the vaccinated blood.Conclusion. It is necessary to note the importance of studying of the human immune status in 1–3 months after plague vaccination as this period coincides with potentially dangerous season from epidemiological point of view. Nevertheless, much important role for improvement of tactics of the specific prevention measures plays the data received after the revaccination.
format	article
author	K. M. Korytov V. V. Voitkova V. I. Dubrovina A. B. Pyatidesyatnikova A. K. Noskov E. A. Glushkov I. S. Akimova N. V. Ondar L. K. Salchak O. S. Mongush A. D. Dazhikay A. A. Saydy Yu. K. Orteney S. V. Balakhonov
author_facet	K. M. Korytov V. V. Voitkova V. I. Dubrovina A. B. Pyatidesyatnikova A. K. Noskov E. A. Glushkov I. S. Akimova N. V. Ondar L. K. Salchak O. S. Mongush A. D. Dazhikay A. A. Saydy Yu. K. Orteney S. V. Balakhonov
author_sort	K. M. Korytov
title	Efficiency of Human Plague Vaccination in Tuvinian Natural Plague Focus
title_short	Efficiency of Human Plague Vaccination in Tuvinian Natural Plague Focus
title_full	Efficiency of Human Plague Vaccination in Tuvinian Natural Plague Focus
title_fullStr	Efficiency of Human Plague Vaccination in Tuvinian Natural Plague Focus
title_full_unstemmed	Efficiency of Human Plague Vaccination in Tuvinian Natural Plague Focus
title_sort	efficiency of human plague vaccination in tuvinian natural plague focus
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/8e413b6a2ebf4ac9861630dc9ba57141
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Efficiency of Human Plague Vaccination in Tuvinian Natural Plague Focus

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