Polymorphism in serotonin receptor 3B is associated with pain catastrophizing.

Pain catastrophizing, a coping style characterized by excessively negative thoughts and emotions in relation to pain, is one of the psychological factors that most markedly predicts variability in the perception of pain; however, only little is known about the underlying neurobiology. The aim of thi...

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Autores principales:	Emilia Horjales-Araujo, Ditte Demontis, Ellen Kielland Lund, Nanna Brix Finnerup, Anders D Børglum, Troels Staehelin Jensen, Peter Svensson, Lene Vase
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e434fada3f54bcdbc52be2c595c5bc9
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spelling	oai:doaj.org-article:8e434fada3f54bcdbc52be2c595c5bc92021-11-18T08:47:30ZPolymorphism in serotonin receptor 3B is associated with pain catastrophizing.1932-620310.1371/journal.pone.0078889https://doaj.org/article/8e434fada3f54bcdbc52be2c595c5bc92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244382/?tool=EBIhttps://doaj.org/toc/1932-6203Pain catastrophizing, a coping style characterized by excessively negative thoughts and emotions in relation to pain, is one of the psychological factors that most markedly predicts variability in the perception of pain; however, only little is known about the underlying neurobiology. The aim of this study was to test for associations between psychological variables, such as pain catastrophizing, anxiety and depression, and selected polymorphisms in genes related to monoaminergic neurotransmission, in particular serotonin pathway genes. Three hundred seventy-nine healthy participants completed a set of psychological questionnaires: the Pain Catastrophizing Scale (PCS), the State-Trait Anxiety Inventory and Beck's Depression Inventory, and were genotyped for 15 single nucleotide polymorphisms (SNPs) in nine genes. The SNP rs1176744 located in the serotonin receptor 3B gene (5-HTR3B) was found to be associated with pain catastrophizing scores: both the global score and the subscales of magnification and helplessness. This is the first study to show an association between 5-HTR3B and PCS scores, thus suggesting a role of the serotonin pathway in pain catastrophizing. Since 5-HTR3B has previously been associated with descending pain modulation pathways, future studies will be of great interest to elucidate the molecular pathways involved in the relation between serotonin, its receptors and pain catastrophizing.Emilia Horjales-AraujoDitte DemontisEllen Kielland LundNanna Brix FinnerupAnders D BørglumTroels Staehelin JensenPeter SvenssonLene VasePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e78889 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emilia Horjales-Araujo Ditte Demontis Ellen Kielland Lund Nanna Brix Finnerup Anders D Børglum Troels Staehelin Jensen Peter Svensson Lene Vase Polymorphism in serotonin receptor 3B is associated with pain catastrophizing.
description	Pain catastrophizing, a coping style characterized by excessively negative thoughts and emotions in relation to pain, is one of the psychological factors that most markedly predicts variability in the perception of pain; however, only little is known about the underlying neurobiology. The aim of this study was to test for associations between psychological variables, such as pain catastrophizing, anxiety and depression, and selected polymorphisms in genes related to monoaminergic neurotransmission, in particular serotonin pathway genes. Three hundred seventy-nine healthy participants completed a set of psychological questionnaires: the Pain Catastrophizing Scale (PCS), the State-Trait Anxiety Inventory and Beck's Depression Inventory, and were genotyped for 15 single nucleotide polymorphisms (SNPs) in nine genes. The SNP rs1176744 located in the serotonin receptor 3B gene (5-HTR3B) was found to be associated with pain catastrophizing scores: both the global score and the subscales of magnification and helplessness. This is the first study to show an association between 5-HTR3B and PCS scores, thus suggesting a role of the serotonin pathway in pain catastrophizing. Since 5-HTR3B has previously been associated with descending pain modulation pathways, future studies will be of great interest to elucidate the molecular pathways involved in the relation between serotonin, its receptors and pain catastrophizing.
format	article
author	Emilia Horjales-Araujo Ditte Demontis Ellen Kielland Lund Nanna Brix Finnerup Anders D Børglum Troels Staehelin Jensen Peter Svensson Lene Vase
author_facet	Emilia Horjales-Araujo Ditte Demontis Ellen Kielland Lund Nanna Brix Finnerup Anders D Børglum Troels Staehelin Jensen Peter Svensson Lene Vase
author_sort	Emilia Horjales-Araujo
title	Polymorphism in serotonin receptor 3B is associated with pain catastrophizing.
title_short	Polymorphism in serotonin receptor 3B is associated with pain catastrophizing.
title_full	Polymorphism in serotonin receptor 3B is associated with pain catastrophizing.
title_fullStr	Polymorphism in serotonin receptor 3B is associated with pain catastrophizing.
title_full_unstemmed	Polymorphism in serotonin receptor 3B is associated with pain catastrophizing.
title_sort	polymorphism in serotonin receptor 3b is associated with pain catastrophizing.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8e434fada3f54bcdbc52be2c595c5bc9
work_keys_str_mv	AT emiliahorjalesaraujo polymorphisminserotoninreceptor3bisassociatedwithpaincatastrophizing AT dittedemontis polymorphisminserotoninreceptor3bisassociatedwithpaincatastrophizing AT ellenkiellandlund polymorphisminserotoninreceptor3bisassociatedwithpaincatastrophizing AT nannabrixfinnerup polymorphisminserotoninreceptor3bisassociatedwithpaincatastrophizing AT andersdbørglum polymorphisminserotoninreceptor3bisassociatedwithpaincatastrophizing AT troelsstaehelinjensen polymorphisminserotoninreceptor3bisassociatedwithpaincatastrophizing AT petersvensson polymorphisminserotoninreceptor3bisassociatedwithpaincatastrophizing AT lenevase polymorphisminserotoninreceptor3bisassociatedwithpaincatastrophizing
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Polymorphism in serotonin receptor 3B is associated with pain catastrophizing.

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