Prenatal and postnatal maternal anxiety and amygdala structure and function in young children

Abstract Anxiety symptoms are relatively common during pregnancy and are associated with behavioural problems in children. The amygdala is involved in emotion regulation, and its volume and function are associated with exposure to prenatal maternal depression. The associations between perinatal mate...

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Autores principales:	Claire Donnici, Xiangyu Long, Deborah Dewey, Nicole Letourneau, Bennett Landman, Yuankai Huo, Catherine Lebel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e4367412d4946fa8df868c8cf244c84
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spelling	oai:doaj.org-article:8e4367412d4946fa8df868c8cf244c842021-12-02T14:03:57ZPrenatal and postnatal maternal anxiety and amygdala structure and function in young children10.1038/s41598-021-83249-22045-2322https://doaj.org/article/8e4367412d4946fa8df868c8cf244c842021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83249-2https://doaj.org/toc/2045-2322Abstract Anxiety symptoms are relatively common during pregnancy and are associated with behavioural problems in children. The amygdala is involved in emotion regulation, and its volume and function are associated with exposure to prenatal maternal depression. The associations between perinatal maternal anxiety and children’s amygdala structure and function remain unclear. The objective of this study was to determine associations between prenatal and postnatal maternal anxiety and amygdala structure and function in children. Maternal anxiety was measured during the second trimester of pregnancy and 12 weeks postpartum. T1-weighted anatomical data and functional magnetic resonance imaging data were collected from 54 children (25 females), between the ages of 3–7 years. Amygdala volume was calculated and functional connectivity maps were created between the amygdalae and the rest of the brain. Spearman correlations were used to test associations between amygdala volume/functional connectivity and maternal anxiety symptoms, controlling for maternal depression symptoms. Second trimester maternal anxiety symptoms were negatively associated with functional connectivity between the left amygdala and clusters in bilateral parietal regions; higher maternal anxiety was associated with increased negative connectivity. Postnatal maternal anxiety symptoms were positively associated with child amygdala volume, but this finding did not remain significant while controlling for total brain volume. These functional connectivity differences may underlie behavioral outcomes in children exposed to maternal anxiety during pregnancy.Claire DonniciXiangyu LongDeborah DeweyNicole LetourneauBennett LandmanYuankai HuoCatherine LebelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claire Donnici Xiangyu Long Deborah Dewey Nicole Letourneau Bennett Landman Yuankai Huo Catherine Lebel Prenatal and postnatal maternal anxiety and amygdala structure and function in young children
description	Abstract Anxiety symptoms are relatively common during pregnancy and are associated with behavioural problems in children. The amygdala is involved in emotion regulation, and its volume and function are associated with exposure to prenatal maternal depression. The associations between perinatal maternal anxiety and children’s amygdala structure and function remain unclear. The objective of this study was to determine associations between prenatal and postnatal maternal anxiety and amygdala structure and function in children. Maternal anxiety was measured during the second trimester of pregnancy and 12 weeks postpartum. T1-weighted anatomical data and functional magnetic resonance imaging data were collected from 54 children (25 females), between the ages of 3–7 years. Amygdala volume was calculated and functional connectivity maps were created between the amygdalae and the rest of the brain. Spearman correlations were used to test associations between amygdala volume/functional connectivity and maternal anxiety symptoms, controlling for maternal depression symptoms. Second trimester maternal anxiety symptoms were negatively associated with functional connectivity between the left amygdala and clusters in bilateral parietal regions; higher maternal anxiety was associated with increased negative connectivity. Postnatal maternal anxiety symptoms were positively associated with child amygdala volume, but this finding did not remain significant while controlling for total brain volume. These functional connectivity differences may underlie behavioral outcomes in children exposed to maternal anxiety during pregnancy.
format	article
author	Claire Donnici Xiangyu Long Deborah Dewey Nicole Letourneau Bennett Landman Yuankai Huo Catherine Lebel
author_facet	Claire Donnici Xiangyu Long Deborah Dewey Nicole Letourneau Bennett Landman Yuankai Huo Catherine Lebel
author_sort	Claire Donnici
title	Prenatal and postnatal maternal anxiety and amygdala structure and function in young children
title_short	Prenatal and postnatal maternal anxiety and amygdala structure and function in young children
title_full	Prenatal and postnatal maternal anxiety and amygdala structure and function in young children
title_fullStr	Prenatal and postnatal maternal anxiety and amygdala structure and function in young children
title_full_unstemmed	Prenatal and postnatal maternal anxiety and amygdala structure and function in young children
title_sort	prenatal and postnatal maternal anxiety and amygdala structure and function in young children
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8e4367412d4946fa8df868c8cf244c84
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Prenatal and postnatal maternal anxiety and amygdala structure and function in young children

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