Triple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases

Xinzhe Yu,1 Wenwen Zhu,2 Yang Di,1 Jichun Gu,1 Zhongyi Guo,1 Hengchao Li,1 Deliang Fu,1 Chen Jin1 1Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai, 2Institute of Functional Nano & Soft Materials, Collaborative Innovation Center of Suzhou Nano Science and Techn...

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Autores principales:	Yu XZ, Zhu W, Di Y, Gu J, Guo Z, Li H, Fu D, Jin C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Theranostic nanoparticles chemotherapy photodynamic therapy pancreatic cancer lymphatic metastases near infrared irradiation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8e4544d1af5a42a6af0b56254b672523
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spelling	oai:doaj.org-article:8e4544d1af5a42a6af0b56254b6725232021-12-02T05:02:15ZTriple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases1178-2013https://doaj.org/article/8e4544d1af5a42a6af0b56254b6725232017-09-01T00:00:00Zhttps://www.dovepress.com/triple-functional-albumin-based-nanoparticles-for-combined-chemotherap-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xinzhe Yu,1 Wenwen Zhu,2 Yang Di,1 Jichun Gu,1 Zhongyi Guo,1 Hengchao Li,1 Deliang Fu,1 Chen Jin1 1Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai, 2Institute of Functional Nano & Soft Materials, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, China Abstract: Lymphatic metastasis is the major metastatic pattern of pancreatic cancer and considered as an independent risk factor of survival. However, there is still no effective way for the diagnosis and treatment for lymphatic metastases of pancreatic cancer. In this study, using albumin as a carrier of gemcitabine (Gem), further modified by pyropheophorbide-a, we have designed and synthesized a nanoparticle (NP) compound named “pheophorbide-a (P@)-Gem-human serum albumin (HSA)-NPs”. By utilization of its tracer ability of lymphatic metastases, which is triggered by near-infrared irradiation and its visible dying ability, the compound is used for drug delivery tracking, meanwhile as a treating drug, as well as the combined effect of photodynamic therapy and chemotherapy. By the nude mice model of lymphatic metastases of pancreatic cancer (BxPC-3-LN7), we aim to explore the feasibility, effectiveness, and biological safety of diagnosis and treatment for the lymphatic metastases of pancreatic cancer by P@-Gem-HSA-NP, thereby, providing new methods and strategies for the study of nanodrug carrier and research on lymphatic metastases of pancreatic cancer. Keywords: theranostic nanoparticles, chemotherapy, photodynamic therapy, pancreatic cancer, lymphatic metastases, near infrared irradiationYu XZZhu WDi YGu JGuo ZLi HFu DJin CDove Medical PressarticleTheranostic nanoparticleschemotherapyphotodynamic therapypancreatic cancerlymphatic metastasesnear infrared irradiationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6771-6785 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Theranostic nanoparticles chemotherapy photodynamic therapy pancreatic cancer lymphatic metastases near infrared irradiation Medicine (General) R5-920
spellingShingle	Theranostic nanoparticles chemotherapy photodynamic therapy pancreatic cancer lymphatic metastases near infrared irradiation Medicine (General) R5-920 Yu XZ Zhu W Di Y Gu J Guo Z Li H Fu D Jin C Triple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases
description	Xinzhe Yu,1 Wenwen Zhu,2 Yang Di,1 Jichun Gu,1 Zhongyi Guo,1 Hengchao Li,1 Deliang Fu,1 Chen Jin1 1Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai, 2Institute of Functional Nano & Soft Materials, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, China Abstract: Lymphatic metastasis is the major metastatic pattern of pancreatic cancer and considered as an independent risk factor of survival. However, there is still no effective way for the diagnosis and treatment for lymphatic metastases of pancreatic cancer. In this study, using albumin as a carrier of gemcitabine (Gem), further modified by pyropheophorbide-a, we have designed and synthesized a nanoparticle (NP) compound named “pheophorbide-a (P@)-Gem-human serum albumin (HSA)-NPs”. By utilization of its tracer ability of lymphatic metastases, which is triggered by near-infrared irradiation and its visible dying ability, the compound is used for drug delivery tracking, meanwhile as a treating drug, as well as the combined effect of photodynamic therapy and chemotherapy. By the nude mice model of lymphatic metastases of pancreatic cancer (BxPC-3-LN7), we aim to explore the feasibility, effectiveness, and biological safety of diagnosis and treatment for the lymphatic metastases of pancreatic cancer by P@-Gem-HSA-NP, thereby, providing new methods and strategies for the study of nanodrug carrier and research on lymphatic metastases of pancreatic cancer. Keywords: theranostic nanoparticles, chemotherapy, photodynamic therapy, pancreatic cancer, lymphatic metastases, near infrared irradiation
format	article
author	Yu XZ Zhu W Di Y Gu J Guo Z Li H Fu D Jin C
author_facet	Yu XZ Zhu W Di Y Gu J Guo Z Li H Fu D Jin C
author_sort	Yu XZ
title	Triple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases
title_short	Triple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases
title_full	Triple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases
title_fullStr	Triple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases
title_full_unstemmed	Triple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases
title_sort	triple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/8e4544d1af5a42a6af0b56254b672523
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_version_	1718400777315155968

Triple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases

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