Inhaled chemotherapy in lung cancer: future concept of nanomedicine

Paul Zarogoulidis1, Ekaterini Chatzaki2, Konstantinos Porpodis1, Kalliopi Domvri1, Wolfgang Hohenforst-Schmidt3, Eugene P Goldberg4, Nikos Karamanos5, Konstantinos Zarogoulidis11Pulmonary Department, &quot;G Papanikolaou&quot; General Hospital, Aristotle University of Thessaloniki, G...

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Autores principales:	Zarogoulidis P, Chatzaki E, Porpodis K, Domvri K, Hohenforst-Schmidt W, Goldberg EP, Karamanos N, Zarogoulidis K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8e464444fa464bd8a3a691fc788e73e6
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spelling	oai:doaj.org-article:8e464444fa464bd8a3a691fc788e73e62021-12-02T02:42:27ZInhaled chemotherapy in lung cancer: future concept of nanomedicine1176-91141178-2013https://doaj.org/article/8e464444fa464bd8a3a691fc788e73e62012-03-01T00:00:00Zhttp://www.dovepress.com/inhaled-chemotherapy-in-lung-cancer-future-concept-of-nanomedicine-a9541https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Paul Zarogoulidis1, Ekaterini Chatzaki2, Konstantinos Porpodis1, Kalliopi Domvri1, Wolfgang Hohenforst-Schmidt3, Eugene P Goldberg4, Nikos Karamanos5, Konstantinos Zarogoulidis11Pulmonary Department, &quot;G Papanikolaou&quot; General Hospital, Aristotle University of Thessaloniki, Greece; 2Pharmacology Laboratory, Medical School, Democritus University of Thrace, Alexandroupolis, Greece; 3II Medical Clinic, Hospital Coburg, University of Wurzburg, Coburg, Germany; 4Biomaterials Science and Engineering, Department of Materials Science and Engineering, University of Florida, FL; 5Biochemistry Laboratory, Department of Chemistry, University of Patra, GreeceAbstract: Regional chemotherapy was first used for lung cancer 30 years ago. Since then, new methods of drug delivery and pharmaceuticals have been investigated in vitro, and in animals and humans. An extensive review of drug delivery systems, pharmaceuticals, patient monitoring, methods of enhancing inhaled drug deposition, safety and efficacy, and also additional applications of inhaled chemotherapy and its advantages and disadvantages are presented. Regional chemotherapy to the lung parenchyma for lung cancer is feasible and efficient. Safety depends on the chemotherapy agent delivered to the lungs and is dose-dependent and time-dependent. Further evaluation is needed to provide data regarding early lung cancer stages, and whether regional chemotherapy can be used as neoadjuvant or adjuvant treatment. Finally, inhaled chemotherapy could one day be administered at home with fewer systemic adverse effects.Keywords: inhaled chemotherapy, carriers, transducersZarogoulidis PChatzaki EPorpodis KDomvri KHohenforst-Schmidt WGoldberg EPKaramanos NZarogoulidis KDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 1551-1572 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zarogoulidis P Chatzaki E Porpodis K Domvri K Hohenforst-Schmidt W Goldberg EP Karamanos N Zarogoulidis K Inhaled chemotherapy in lung cancer: future concept of nanomedicine
description	Paul Zarogoulidis1, Ekaterini Chatzaki2, Konstantinos Porpodis1, Kalliopi Domvri1, Wolfgang Hohenforst-Schmidt3, Eugene P Goldberg4, Nikos Karamanos5, Konstantinos Zarogoulidis11Pulmonary Department, &quot;G Papanikolaou&quot; General Hospital, Aristotle University of Thessaloniki, Greece; 2Pharmacology Laboratory, Medical School, Democritus University of Thrace, Alexandroupolis, Greece; 3II Medical Clinic, Hospital Coburg, University of Wurzburg, Coburg, Germany; 4Biomaterials Science and Engineering, Department of Materials Science and Engineering, University of Florida, FL; 5Biochemistry Laboratory, Department of Chemistry, University of Patra, GreeceAbstract: Regional chemotherapy was first used for lung cancer 30 years ago. Since then, new methods of drug delivery and pharmaceuticals have been investigated in vitro, and in animals and humans. An extensive review of drug delivery systems, pharmaceuticals, patient monitoring, methods of enhancing inhaled drug deposition, safety and efficacy, and also additional applications of inhaled chemotherapy and its advantages and disadvantages are presented. Regional chemotherapy to the lung parenchyma for lung cancer is feasible and efficient. Safety depends on the chemotherapy agent delivered to the lungs and is dose-dependent and time-dependent. Further evaluation is needed to provide data regarding early lung cancer stages, and whether regional chemotherapy can be used as neoadjuvant or adjuvant treatment. Finally, inhaled chemotherapy could one day be administered at home with fewer systemic adverse effects.Keywords: inhaled chemotherapy, carriers, transducers
format	article
author	Zarogoulidis P Chatzaki E Porpodis K Domvri K Hohenforst-Schmidt W Goldberg EP Karamanos N Zarogoulidis K
author_facet	Zarogoulidis P Chatzaki E Porpodis K Domvri K Hohenforst-Schmidt W Goldberg EP Karamanos N Zarogoulidis K
author_sort	Zarogoulidis P
title	Inhaled chemotherapy in lung cancer: future concept of nanomedicine
title_short	Inhaled chemotherapy in lung cancer: future concept of nanomedicine
title_full	Inhaled chemotherapy in lung cancer: future concept of nanomedicine
title_fullStr	Inhaled chemotherapy in lung cancer: future concept of nanomedicine
title_full_unstemmed	Inhaled chemotherapy in lung cancer: future concept of nanomedicine
title_sort	inhaled chemotherapy in lung cancer: future concept of nanomedicine
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/8e464444fa464bd8a3a691fc788e73e6
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Inhaled chemotherapy in lung cancer: future concept of nanomedicine

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