Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal.

Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal.

<h4>Background</h4>The development of arsenical and diamidine resistance in Trypanosoma brucei is associated with loss of drug uptake by the P2 purine transporter as a result of alterations in the corresponding T. brucei adenosine transporter 1 gene (TbAT1). Previously, specific TbAT1 mu...

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Autores principales: Anne J N Kazibwe, Barbara Nerima, Harry P de Koning, Pascal Mäser, Michael P Barrett, Enock Matovu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
Materias:
Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Acceso en línea:https://doaj.org/article/8e4736c401c44825b1d672bb2e3d6922
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