Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice

Tzong-Shiue Yu et al. assess the impact of astrocytic ApoE on hippocampal neurogenesis and behavior after traumatic brain injury (TBI) in mice. Their results suggest that postnatal ablation of astrocytic APOE reduces dendritic complexity in newborn dentate gyrus neurons and cognitive ability, provid...

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Autores principales:	Tzong-Shiue Yu, Yacine Tensaouti, Elizabeth P. Stephanz, Sana Chintamen, Elizabeth E. Rafikian, Mu Yang, Steven G. Kernie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8e490df72bc349c28fdbc9e8ef79a769
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spelling	oai:doaj.org-article:8e490df72bc349c28fdbc9e8ef79a7692021-11-21T12:08:23ZAstrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice10.1038/s42003-021-02841-42399-3642https://doaj.org/article/8e490df72bc349c28fdbc9e8ef79a7692021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02841-4https://doaj.org/toc/2399-3642Tzong-Shiue Yu et al. assess the impact of astrocytic ApoE on hippocampal neurogenesis and behavior after traumatic brain injury (TBI) in mice. Their results suggest that postnatal ablation of astrocytic APOE reduces dendritic complexity in newborn dentate gyrus neurons and cognitive ability, providing further insight into a role for APOE in injury-induced neurogenesis following TBI.Tzong-Shiue YuYacine TensaoutiElizabeth P. StephanzSana ChintamenElizabeth E. RafikianMu YangSteven G. KernieNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Tzong-Shiue Yu Yacine Tensaouti Elizabeth P. Stephanz Sana Chintamen Elizabeth E. Rafikian Mu Yang Steven G. Kernie Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice
description	Tzong-Shiue Yu et al. assess the impact of astrocytic ApoE on hippocampal neurogenesis and behavior after traumatic brain injury (TBI) in mice. Their results suggest that postnatal ablation of astrocytic APOE reduces dendritic complexity in newborn dentate gyrus neurons and cognitive ability, providing further insight into a role for APOE in injury-induced neurogenesis following TBI.
format	article
author	Tzong-Shiue Yu Yacine Tensaouti Elizabeth P. Stephanz Sana Chintamen Elizabeth E. Rafikian Mu Yang Steven G. Kernie
author_facet	Tzong-Shiue Yu Yacine Tensaouti Elizabeth P. Stephanz Sana Chintamen Elizabeth E. Rafikian Mu Yang Steven G. Kernie
author_sort	Tzong-Shiue Yu
title	Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice
title_short	Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice
title_full	Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice
title_fullStr	Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice
title_full_unstemmed	Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice
title_sort	astrocytic apoe underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8e490df72bc349c28fdbc9e8ef79a769
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Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice

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