Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status

The role of neutrophils in the regulation of tumour growth and metastasis remains controversial. Here, the authors demonstrate that neutrophils, by exerting inhibitory effects on cytotoxic NK cells, show a net pro-metastatic effect in immune-competent mice, while they are tumoricidal and anti-metast...

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Autores principales:	Peishan Li, Ming Lu, Jiayuan Shi, Li Hua, Zheng Gong, Qing Li, Leonard D. Shultz, Guangwen Ren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e4a51d014ec4176905300fb5f285823
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spelling	oai:doaj.org-article:8e4a51d014ec4176905300fb5f2858232021-12-02T19:09:20ZDual roles of neutrophils in metastatic colonization are governed by the host NK cell status10.1038/s41467-020-18125-02041-1723https://doaj.org/article/8e4a51d014ec4176905300fb5f2858232020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18125-0https://doaj.org/toc/2041-1723The role of neutrophils in the regulation of tumour growth and metastasis remains controversial. Here, the authors demonstrate that neutrophils, by exerting inhibitory effects on cytotoxic NK cells, show a net pro-metastatic effect in immune-competent mice, while they are tumoricidal and anti-metastatic in NK cell-deficient hosts.Peishan LiMing LuJiayuan ShiLi HuaZheng GongQing LiLeonard D. ShultzGuangwen RenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peishan Li Ming Lu Jiayuan Shi Li Hua Zheng Gong Qing Li Leonard D. Shultz Guangwen Ren Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
description	The role of neutrophils in the regulation of tumour growth and metastasis remains controversial. Here, the authors demonstrate that neutrophils, by exerting inhibitory effects on cytotoxic NK cells, show a net pro-metastatic effect in immune-competent mice, while they are tumoricidal and anti-metastatic in NK cell-deficient hosts.
format	article
author	Peishan Li Ming Lu Jiayuan Shi Li Hua Zheng Gong Qing Li Leonard D. Shultz Guangwen Ren
author_facet	Peishan Li Ming Lu Jiayuan Shi Li Hua Zheng Gong Qing Li Leonard D. Shultz Guangwen Ren
author_sort	Peishan Li
title	Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
title_short	Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
title_full	Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
title_fullStr	Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
title_full_unstemmed	Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
title_sort	dual roles of neutrophils in metastatic colonization are governed by the host nk cell status
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8e4a51d014ec4176905300fb5f285823
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Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status

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