Effects of bromadiolone poisoning on the central nervous system

Meiling Wang,1 Yanfeng Yang,2 Yiwei Hou,1 Wenbin Ma,1 Rui Jia,1 Jinbo Chen1 1Neurology Department, Binzhou Medical University Hospital, Binzhou Medical University, 2Binzhou Blood Center, Binzhou, China Abstract: Cases of rodenticide poisoning (second-generation long-acting dicoumarin rode...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang M, Yang Y, Hou Y, Ma W, Jia R, Chen J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Bromadiolone poisoning central nervous system superwarfarin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8e4d2eb61d3c4fe980ec10d0d8da16e4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8e4d2eb61d3c4fe980ec10d0d8da16e4
record_format	dspace
spelling	oai:doaj.org-article:8e4d2eb61d3c4fe980ec10d0d8da16e42021-12-02T01:17:55ZEffects of bromadiolone poisoning on the central nervous system1178-2021https://doaj.org/article/8e4d2eb61d3c4fe980ec10d0d8da16e42017-08-01T00:00:00Zhttps://www.dovepress.com/effects-of-bromadiolone-poisoning-on-the-central-nervous-system-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Meiling Wang,1 Yanfeng Yang,2 Yiwei Hou,1 Wenbin Ma,1 Rui Jia,1 Jinbo Chen1 1Neurology Department, Binzhou Medical University Hospital, Binzhou Medical University, 2Binzhou Blood Center, Binzhou, China Abstract: Cases of rodenticide poisoning (second-generation long-acting dicoumarin rodenticide, superwarfarin) have occasionally been reported. The main symptoms of bromadiolone poisoning are skin mucosa hemorrhage, digestive tract hemorrhage, and hematuresis. However, the symptoms of central nervous system toxicity have rarely been reported. Our case reports on a 41-year-old male who had no contact with bromadiolone. His main symptoms were dizziness, unsteady gait, and abnormal behavior. Laboratory test results revealed the presence of bromadiolone in his blood and urine, a longer prothrombin time, activated partial thromboplastin time, and a high international normalized ratio. Magnetic resonance imaging of the brain showed that the bilateral posterior limb of the internal capsule, splenium of corporis callosum, and bilateral centrum semiovale formed symmetrical patch distribution. The patient gradually recovered after treated with vitamin K1 and plasma transfusion. Our clinical study could pave the way to improve the detection of bromadiolone poisoning and avoid misdiagnosis. Keywords: bromadiolone, poisoning, central nervous system, superwarfarinWang MYang YHou YMa WJia RChen JDove Medical PressarticleBromadiolonepoisoningcentral nervous systemsuperwarfarinNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2297-2300 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bromadiolone poisoning central nervous system superwarfarin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Bromadiolone poisoning central nervous system superwarfarin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang M Yang Y Hou Y Ma W Jia R Chen J Effects of bromadiolone poisoning on the central nervous system
description	Meiling Wang,1 Yanfeng Yang,2 Yiwei Hou,1 Wenbin Ma,1 Rui Jia,1 Jinbo Chen1 1Neurology Department, Binzhou Medical University Hospital, Binzhou Medical University, 2Binzhou Blood Center, Binzhou, China Abstract: Cases of rodenticide poisoning (second-generation long-acting dicoumarin rodenticide, superwarfarin) have occasionally been reported. The main symptoms of bromadiolone poisoning are skin mucosa hemorrhage, digestive tract hemorrhage, and hematuresis. However, the symptoms of central nervous system toxicity have rarely been reported. Our case reports on a 41-year-old male who had no contact with bromadiolone. His main symptoms were dizziness, unsteady gait, and abnormal behavior. Laboratory test results revealed the presence of bromadiolone in his blood and urine, a longer prothrombin time, activated partial thromboplastin time, and a high international normalized ratio. Magnetic resonance imaging of the brain showed that the bilateral posterior limb of the internal capsule, splenium of corporis callosum, and bilateral centrum semiovale formed symmetrical patch distribution. The patient gradually recovered after treated with vitamin K1 and plasma transfusion. Our clinical study could pave the way to improve the detection of bromadiolone poisoning and avoid misdiagnosis. Keywords: bromadiolone, poisoning, central nervous system, superwarfarin
format	article
author	Wang M Yang Y Hou Y Ma W Jia R Chen J
author_facet	Wang M Yang Y Hou Y Ma W Jia R Chen J
author_sort	Wang M
title	Effects of bromadiolone poisoning on the central nervous system
title_short	Effects of bromadiolone poisoning on the central nervous system
title_full	Effects of bromadiolone poisoning on the central nervous system
title_fullStr	Effects of bromadiolone poisoning on the central nervous system
title_full_unstemmed	Effects of bromadiolone poisoning on the central nervous system
title_sort	effects of bromadiolone poisoning on the central nervous system
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/8e4d2eb61d3c4fe980ec10d0d8da16e4
work_keys_str_mv	AT wangm effectsofbromadiolonepoisoningonthecentralnervoussystem AT yangy effectsofbromadiolonepoisoningonthecentralnervoussystem AT houy effectsofbromadiolonepoisoningonthecentralnervoussystem AT maw effectsofbromadiolonepoisoningonthecentralnervoussystem AT jiar effectsofbromadiolonepoisoningonthecentralnervoussystem AT chenj effectsofbromadiolonepoisoningonthecentralnervoussystem
_version_	1718403150407270400

Effects of bromadiolone poisoning on the central nervous system

Ejemplares similares