Maternal Diet, Infection, and Risk of Cord Blood Inflammation in the Bangladesh Projahnmo Pregnancy Cohort
Inflammation may adversely affect early human brain development. We aimed to assess the role of maternal nutrition and infections on cord blood inflammation. In a pregnancy cohort in Sylhet, Bangladesh, we enrolled 251 consecutive pregnancies resulting in a term livebirth from July 2016–March 2017....
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MDPI AG
2021
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oai:doaj.org-article:8e561cde9a2349d0ac57666c49d550b32021-11-25T18:34:06ZMaternal Diet, Infection, and Risk of Cord Blood Inflammation in the Bangladesh Projahnmo Pregnancy Cohort10.3390/nu131137922072-6643https://doaj.org/article/8e561cde9a2349d0ac57666c49d550b32021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3792https://doaj.org/toc/2072-6643Inflammation may adversely affect early human brain development. We aimed to assess the role of maternal nutrition and infections on cord blood inflammation. In a pregnancy cohort in Sylhet, Bangladesh, we enrolled 251 consecutive pregnancies resulting in a term livebirth from July 2016–March 2017. Stillbirths, preterm births, and cases of neonatal encephalopathy were excluded. We prospectively collected data on maternal diet (food frequency questionnaire) and morbidity, and analyzed umbilical cord blood for interleukin (IL)-1α, IL-1β, IL-6, IL-8 and C-reactive protein. We determined associations between nutrition and infection exposures and cord cytokine elevation (≥75% vs. <75%) using logistic regression, adjusting for confounders. One-third of mothers were underweight (BMI < 18.5 kg/m<sup>2</sup>) at enrollment. Antenatal and intrapartum infections were observed among 4.8% and 15.9% of the sample, respectively. Low pregnancy intakes of B vitamins (B1, B2, B3, B6, B9 (folate)), fat-soluble vitamins (D, E), iron, zinc, and linoleic acid (lowest vs. middle tertile) were associated with higher risk of inflammation, particularly IL-8. There was a non-significant trend of increased risk of IL-8 and IL-6 elevation with history of ante-and intrapartum infections, respectively. In Bangladesh, improving micronutrient intake and preventing pregnancy infections are targets to reduce fetal systemic inflammation and associated adverse neurodevelopmental outcomes.Anne CC LeeSara CherkerzianIngrid E OlsonSalahuddin AhmedNabidul Haque ChowdhuryRasheda KhanamSayedur RahmanChloe AndrewsAbdullah H BaquiWafaie FawziTerrie E InderStephanie NarteyCharles A NelsonEmily OkenSarbattama SenRaina FichorovaMDPI AGarticleundernutritionprenatal infectioninflammationmicronutrientNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3792, p 3792 (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
undernutrition prenatal infection inflammation micronutrient Nutrition. Foods and food supply TX341-641 |
| spellingShingle |
undernutrition prenatal infection inflammation micronutrient Nutrition. Foods and food supply TX341-641 Anne CC Lee Sara Cherkerzian Ingrid E Olson Salahuddin Ahmed Nabidul Haque Chowdhury Rasheda Khanam Sayedur Rahman Chloe Andrews Abdullah H Baqui Wafaie Fawzi Terrie E Inder Stephanie Nartey Charles A Nelson Emily Oken Sarbattama Sen Raina Fichorova Maternal Diet, Infection, and Risk of Cord Blood Inflammation in the Bangladesh Projahnmo Pregnancy Cohort |
| description |
Inflammation may adversely affect early human brain development. We aimed to assess the role of maternal nutrition and infections on cord blood inflammation. In a pregnancy cohort in Sylhet, Bangladesh, we enrolled 251 consecutive pregnancies resulting in a term livebirth from July 2016–March 2017. Stillbirths, preterm births, and cases of neonatal encephalopathy were excluded. We prospectively collected data on maternal diet (food frequency questionnaire) and morbidity, and analyzed umbilical cord blood for interleukin (IL)-1α, IL-1β, IL-6, IL-8 and C-reactive protein. We determined associations between nutrition and infection exposures and cord cytokine elevation (≥75% vs. <75%) using logistic regression, adjusting for confounders. One-third of mothers were underweight (BMI < 18.5 kg/m<sup>2</sup>) at enrollment. Antenatal and intrapartum infections were observed among 4.8% and 15.9% of the sample, respectively. Low pregnancy intakes of B vitamins (B1, B2, B3, B6, B9 (folate)), fat-soluble vitamins (D, E), iron, zinc, and linoleic acid (lowest vs. middle tertile) were associated with higher risk of inflammation, particularly IL-8. There was a non-significant trend of increased risk of IL-8 and IL-6 elevation with history of ante-and intrapartum infections, respectively. In Bangladesh, improving micronutrient intake and preventing pregnancy infections are targets to reduce fetal systemic inflammation and associated adverse neurodevelopmental outcomes. |
| format |
article |
| author |
Anne CC Lee Sara Cherkerzian Ingrid E Olson Salahuddin Ahmed Nabidul Haque Chowdhury Rasheda Khanam Sayedur Rahman Chloe Andrews Abdullah H Baqui Wafaie Fawzi Terrie E Inder Stephanie Nartey Charles A Nelson Emily Oken Sarbattama Sen Raina Fichorova |
| author_facet |
Anne CC Lee Sara Cherkerzian Ingrid E Olson Salahuddin Ahmed Nabidul Haque Chowdhury Rasheda Khanam Sayedur Rahman Chloe Andrews Abdullah H Baqui Wafaie Fawzi Terrie E Inder Stephanie Nartey Charles A Nelson Emily Oken Sarbattama Sen Raina Fichorova |
| author_sort |
Anne CC Lee |
| title |
Maternal Diet, Infection, and Risk of Cord Blood Inflammation in the Bangladesh Projahnmo Pregnancy Cohort |
| title_short |
Maternal Diet, Infection, and Risk of Cord Blood Inflammation in the Bangladesh Projahnmo Pregnancy Cohort |
| title_full |
Maternal Diet, Infection, and Risk of Cord Blood Inflammation in the Bangladesh Projahnmo Pregnancy Cohort |
| title_fullStr |
Maternal Diet, Infection, and Risk of Cord Blood Inflammation in the Bangladesh Projahnmo Pregnancy Cohort |
| title_full_unstemmed |
Maternal Diet, Infection, and Risk of Cord Blood Inflammation in the Bangladesh Projahnmo Pregnancy Cohort |
| title_sort |
maternal diet, infection, and risk of cord blood inflammation in the bangladesh projahnmo pregnancy cohort |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/8e561cde9a2349d0ac57666c49d550b3 |
| work_keys_str_mv |
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| _version_ |
1718410965357166592 |