A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men

Abstract Regular physical exercise enhances memory functions, synaptic plasticity in the hippocampus, and brain derived neurotrophic factor (BDNF) levels. Likewise, short periods of exercise, or acute exercise, benefit hippocampal plasticity in rodents, via increased endocannabinoids (especially ana...

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Autores principales:	Blanca Marin Bosch, Aurélien Bringard, Maria G. Logrieco, Estelle Lauer, Nathalie Imobersteg, Aurélien Thomas, Guido Ferretti, Sophie Schwartz, Kinga Igloi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e578dc02b464f599e2a2eb20d761c46
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spelling	oai:doaj.org-article:8e578dc02b464f599e2a2eb20d761c462021-12-02T16:08:08ZA single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men10.1038/s41598-021-93813-52045-2322https://doaj.org/article/8e578dc02b464f599e2a2eb20d761c462021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93813-5https://doaj.org/toc/2045-2322Abstract Regular physical exercise enhances memory functions, synaptic plasticity in the hippocampus, and brain derived neurotrophic factor (BDNF) levels. Likewise, short periods of exercise, or acute exercise, benefit hippocampal plasticity in rodents, via increased endocannabinoids (especially anandamide, AEA) and BDNF release. Yet, it remains unknown whether acute exercise has similar effects on BDNF and AEA levels in humans, with parallel influences on memory performance. Here we combined blood biomarkers, behavioral, and fMRI measurements to assess the impact of a single session of physical exercise on associative memory and underlying neurophysiological mechanisms in healthy male volunteers. For each participant, memory was tested after three conditions: rest, moderate or high intensity exercise. A long-term memory retest took place 3 months later. At both test and retest, memory performance after moderate intensity exercise was increased compared to rest. Memory after moderate intensity exercise correlated with exercise-induced increases in both AEA and BNDF levels: while AEA was associated with hippocampal activity during memory recall, BDNF enhanced hippocampal memory representations and long-term performance. These findings demonstrate that acute moderate intensity exercise benefits consolidation of hippocampal memory representations, and that endocannabinoids and BNDF signaling may contribute to the synergic modulation of underlying neural plasticity mechanisms.Blanca Marin BoschAurélien BringardMaria G. LogriecoEstelle LauerNathalie ImoberstegAurélien ThomasGuido FerrettiSophie SchwartzKinga IgloiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Blanca Marin Bosch Aurélien Bringard Maria G. Logrieco Estelle Lauer Nathalie Imobersteg Aurélien Thomas Guido Ferretti Sophie Schwartz Kinga Igloi A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men
description	Abstract Regular physical exercise enhances memory functions, synaptic plasticity in the hippocampus, and brain derived neurotrophic factor (BDNF) levels. Likewise, short periods of exercise, or acute exercise, benefit hippocampal plasticity in rodents, via increased endocannabinoids (especially anandamide, AEA) and BDNF release. Yet, it remains unknown whether acute exercise has similar effects on BDNF and AEA levels in humans, with parallel influences on memory performance. Here we combined blood biomarkers, behavioral, and fMRI measurements to assess the impact of a single session of physical exercise on associative memory and underlying neurophysiological mechanisms in healthy male volunteers. For each participant, memory was tested after three conditions: rest, moderate or high intensity exercise. A long-term memory retest took place 3 months later. At both test and retest, memory performance after moderate intensity exercise was increased compared to rest. Memory after moderate intensity exercise correlated with exercise-induced increases in both AEA and BNDF levels: while AEA was associated with hippocampal activity during memory recall, BDNF enhanced hippocampal memory representations and long-term performance. These findings demonstrate that acute moderate intensity exercise benefits consolidation of hippocampal memory representations, and that endocannabinoids and BNDF signaling may contribute to the synergic modulation of underlying neural plasticity mechanisms.
format	article
author	Blanca Marin Bosch Aurélien Bringard Maria G. Logrieco Estelle Lauer Nathalie Imobersteg Aurélien Thomas Guido Ferretti Sophie Schwartz Kinga Igloi
author_facet	Blanca Marin Bosch Aurélien Bringard Maria G. Logrieco Estelle Lauer Nathalie Imobersteg Aurélien Thomas Guido Ferretti Sophie Schwartz Kinga Igloi
author_sort	Blanca Marin Bosch
title	A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men
title_short	A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men
title_full	A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men
title_fullStr	A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men
title_full_unstemmed	A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men
title_sort	single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8e578dc02b464f599e2a2eb20d761c46
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A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men

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