FEATURES OF NK-CELL CONTENTS IN PATIENTS WITH CHRONIC HEPATITIS C

Abstract. Clinical course and outcomes in chronic hepatitis C (CHC) depend on the state of cellular immunity in the patients. We have analyzed some indexes bearing on absolute and relative contents of NK-cells (CD3-CD16+CD56+), and their activated forms (CD3-CD16+CD56+CD107+a), as estimated by the L...

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Autores principales:	M. S. Selkova, O. V. Nikitina, V. A. Mikhailova, E. V. Esaulenko, A.V. Seliutin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	activated nk-cells chronic hepatitis c cd107a flow cytometry Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8e58fc65fefe4a0f99e0a82f32e0a8e1
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spelling	oai:doaj.org-article:8e58fc65fefe4a0f99e0a82f32e0a8e12021-11-18T08:03:40ZFEATURES OF NK-CELL CONTENTS IN PATIENTS WITH CHRONIC HEPATITIS C1563-06252313-741X10.15789/1563-0625-2012-4-5-439-444https://doaj.org/article/8e58fc65fefe4a0f99e0a82f32e0a8e12014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/384https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Clinical course and outcomes in chronic hepatitis C (CHC) depend on the state of cellular immunity in the patients. We have analyzed some indexes bearing on absolute and relative contents of NK-cells (CD3-CD16+CD56+), and their activated forms (CD3-CD16+CD56+CD107+a), as estimated by the LAMP-protein (CD107a) expression in peripheral blood of seventy patients with verified diagnosis of CHC. A significant reduction in cytotoxic potential of NK cells was revealed in patients with chronic hepatitis C, in spite of normal absolute amounts of total NK-cells. It was revealed that the levels of NK-cells and their activated forms did not did not depend on HCV genotype (1 vs 3). Likewise, they did not differ between the patients with higher and lower viral load. When analyzing relationships between the contents of activated NK cells and levels of biochemical markers of cytolytic and cholestatic syndromes, we have found a direct correlation with AST activity, and an inverse correlation with the of GGT and alkaline phosphatase activities. The data suggest a possible role of altered NK cell activation in pathogenesis of chronic hepatitis C.M. S. SelkovaO. V. NikitinaV. A. MikhailovaE. V. EsaulenkoA.V. SeliutinSPb RAACIarticleactivated nk-cellschronic hepatitis ccd107aflow cytometryImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 4-5, Pp 439-444 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	activated nk-cells chronic hepatitis c cd107a flow cytometry Immunologic diseases. Allergy RC581-607
spellingShingle	activated nk-cells chronic hepatitis c cd107a flow cytometry Immunologic diseases. Allergy RC581-607 M. S. Selkova O. V. Nikitina V. A. Mikhailova E. V. Esaulenko A.V. Seliutin FEATURES OF NK-CELL CONTENTS IN PATIENTS WITH CHRONIC HEPATITIS C
description	Abstract. Clinical course and outcomes in chronic hepatitis C (CHC) depend on the state of cellular immunity in the patients. We have analyzed some indexes bearing on absolute and relative contents of NK-cells (CD3-CD16+CD56+), and their activated forms (CD3-CD16+CD56+CD107+a), as estimated by the LAMP-protein (CD107a) expression in peripheral blood of seventy patients with verified diagnosis of CHC. A significant reduction in cytotoxic potential of NK cells was revealed in patients with chronic hepatitis C, in spite of normal absolute amounts of total NK-cells. It was revealed that the levels of NK-cells and their activated forms did not did not depend on HCV genotype (1 vs 3). Likewise, they did not differ between the patients with higher and lower viral load. When analyzing relationships between the contents of activated NK cells and levels of biochemical markers of cytolytic and cholestatic syndromes, we have found a direct correlation with AST activity, and an inverse correlation with the of GGT and alkaline phosphatase activities. The data suggest a possible role of altered NK cell activation in pathogenesis of chronic hepatitis C.
format	article
author	M. S. Selkova O. V. Nikitina V. A. Mikhailova E. V. Esaulenko A.V. Seliutin
author_facet	M. S. Selkova O. V. Nikitina V. A. Mikhailova E. V. Esaulenko A.V. Seliutin
author_sort	M. S. Selkova
title	FEATURES OF NK-CELL CONTENTS IN PATIENTS WITH CHRONIC HEPATITIS C
title_short	FEATURES OF NK-CELL CONTENTS IN PATIENTS WITH CHRONIC HEPATITIS C
title_full	FEATURES OF NK-CELL CONTENTS IN PATIENTS WITH CHRONIC HEPATITIS C
title_fullStr	FEATURES OF NK-CELL CONTENTS IN PATIENTS WITH CHRONIC HEPATITIS C
title_full_unstemmed	FEATURES OF NK-CELL CONTENTS IN PATIENTS WITH CHRONIC HEPATITIS C
title_sort	features of nk-cell contents in patients with chronic hepatitis c
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8e58fc65fefe4a0f99e0a82f32e0a8e1
work_keys_str_mv	AT msselkova featuresofnkcellcontentsinpatientswithchronichepatitisc AT ovnikitina featuresofnkcellcontentsinpatientswithchronichepatitisc AT vamikhailova featuresofnkcellcontentsinpatientswithchronichepatitisc AT evesaulenko featuresofnkcellcontentsinpatientswithchronichepatitisc AT avseliutin featuresofnkcellcontentsinpatientswithchronichepatitisc
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FEATURES OF NK-CELL CONTENTS IN PATIENTS WITH CHRONIC HEPATITIS C

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