CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Low density lipoprotein receptor (LDLR) is crucial for cholesterol homeostasis. Here, the authors show that components of the CCC-protein complex, CCDC22 and COMMD1, facilitate the endosomal sorting of LDLR and that mutations in these genes cause hypercholesterolemia in dogs and mice, providing new...

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Autores principales:	Paulina Bartuzi, Daniel D. Billadeau, Robert Favier, Shunxing Rong, Daphne Dekker, Alina Fedoseienko, Hille Fieten, Melinde Wijers, Johannes H. Levels, Nicolette Huijkman, Niels Kloosterhuis, Henk van der Molen, Gemma Brufau, Albert K. Groen, Alison M. Elliott, Jan Albert Kuivenhoven, Barbara Plecko, Gernot Grangl, Julie McGaughran, Jay D. Horton, Ezra Burstein, Marten H. Hofker, Bart van de Sluis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e60ef48969c43c189785a273159992f
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spelling	oai:doaj.org-article:8e60ef48969c43c189785a273159992f2021-12-02T16:57:40ZCCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL10.1038/ncomms109612041-1723https://doaj.org/article/8e60ef48969c43c189785a273159992f2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10961https://doaj.org/toc/2041-1723Low density lipoprotein receptor (LDLR) is crucial for cholesterol homeostasis. Here, the authors show that components of the CCC-protein complex, CCDC22 and COMMD1, facilitate the endosomal sorting of LDLR and that mutations in these genes cause hypercholesterolemia in dogs and mice, providing new insights into regulation of cholesterol homeostasis.Paulina BartuziDaniel D. BilladeauRobert FavierShunxing RongDaphne DekkerAlina FedoseienkoHille FietenMelinde WijersJohannes H. LevelsNicolette HuijkmanNiels KloosterhuisHenk van der MolenGemma BrufauAlbert K. GroenAlison M. ElliottJan Albert KuivenhovenBarbara PleckoGernot GranglJulie McGaughranJay D. HortonEzra BursteinMarten H. HofkerBart van de SluisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paulina Bartuzi Daniel D. Billadeau Robert Favier Shunxing Rong Daphne Dekker Alina Fedoseienko Hille Fieten Melinde Wijers Johannes H. Levels Nicolette Huijkman Niels Kloosterhuis Henk van der Molen Gemma Brufau Albert K. Groen Alison M. Elliott Jan Albert Kuivenhoven Barbara Plecko Gernot Grangl Julie McGaughran Jay D. Horton Ezra Burstein Marten H. Hofker Bart van de Sluis CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
description	Low density lipoprotein receptor (LDLR) is crucial for cholesterol homeostasis. Here, the authors show that components of the CCC-protein complex, CCDC22 and COMMD1, facilitate the endosomal sorting of LDLR and that mutations in these genes cause hypercholesterolemia in dogs and mice, providing new insights into regulation of cholesterol homeostasis.
format	article
author	Paulina Bartuzi Daniel D. Billadeau Robert Favier Shunxing Rong Daphne Dekker Alina Fedoseienko Hille Fieten Melinde Wijers Johannes H. Levels Nicolette Huijkman Niels Kloosterhuis Henk van der Molen Gemma Brufau Albert K. Groen Alison M. Elliott Jan Albert Kuivenhoven Barbara Plecko Gernot Grangl Julie McGaughran Jay D. Horton Ezra Burstein Marten H. Hofker Bart van de Sluis
author_facet	Paulina Bartuzi Daniel D. Billadeau Robert Favier Shunxing Rong Daphne Dekker Alina Fedoseienko Hille Fieten Melinde Wijers Johannes H. Levels Nicolette Huijkman Niels Kloosterhuis Henk van der Molen Gemma Brufau Albert K. Groen Alison M. Elliott Jan Albert Kuivenhoven Barbara Plecko Gernot Grangl Julie McGaughran Jay D. Horton Ezra Burstein Marten H. Hofker Bart van de Sluis
author_sort	Paulina Bartuzi
title	CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
title_short	CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
title_full	CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
title_fullStr	CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
title_full_unstemmed	CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
title_sort	ccc- and wash-mediated endosomal sorting of ldlr is required for normal clearance of circulating ldl
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8e60ef48969c43c189785a273159992f
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CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

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