Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II

Cdk9 (P-TEFb) and its substrate Spt5 influence events throughout the transcription cycle. Here, the authors define two switches with the potential to regulate promoter-proximal pause release and termination, respectively containing phosphatases PP4 and PP1, which are both inhibited by Cdk9, but have...

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Autores principales:	Pabitra K. Parua, Sampada Kalan, Bradley Benjamin, Miriam Sansó, Robert P. Fisher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e61f919126a433ba10ee6df1e7aa926
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spelling	oai:doaj.org-article:8e61f919126a433ba10ee6df1e7aa9262021-12-02T19:02:36ZDistinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II10.1038/s41467-020-18173-62041-1723https://doaj.org/article/8e61f919126a433ba10ee6df1e7aa9262020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18173-6https://doaj.org/toc/2041-1723Cdk9 (P-TEFb) and its substrate Spt5 influence events throughout the transcription cycle. Here, the authors define two switches with the potential to regulate promoter-proximal pause release and termination, respectively containing phosphatases PP4 and PP1, which are both inhibited by Cdk9, but have different specificities for sites on Spt5 and occupy opposite ends of genes.Pabitra K. ParuaSampada KalanBradley BenjaminMiriam SansóRobert P. FisherNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pabitra K. Parua Sampada Kalan Bradley Benjamin Miriam Sansó Robert P. Fisher Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II
description	Cdk9 (P-TEFb) and its substrate Spt5 influence events throughout the transcription cycle. Here, the authors define two switches with the potential to regulate promoter-proximal pause release and termination, respectively containing phosphatases PP4 and PP1, which are both inhibited by Cdk9, but have different specificities for sites on Spt5 and occupy opposite ends of genes.
format	article
author	Pabitra K. Parua Sampada Kalan Bradley Benjamin Miriam Sansó Robert P. Fisher
author_facet	Pabitra K. Parua Sampada Kalan Bradley Benjamin Miriam Sansó Robert P. Fisher
author_sort	Pabitra K. Parua
title	Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II
title_short	Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II
title_full	Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II
title_fullStr	Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II
title_full_unstemmed	Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II
title_sort	distinct cdk9-phosphatase switches act at the beginning and end of elongation by rna polymerase ii
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8e61f919126a433ba10ee6df1e7aa926
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Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II

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