Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies
Reihaneh Haghniaz, Rinku D Umrani, Kishore M Paknikar Centre for Nanobioscience, Agharkar Research Institute, Pune, India Purpose: The aim of this study was to evaluate radiofrequency-induced dextran-coated lanthanum strontium manganese oxide nanoparticles-mediated hyperthermia to be used for tumo...
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Dove Medical Press
2016
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oai:doaj.org-article:8e651498b70a43899bab6b4ee4c85b282021-12-02T00:46:37ZHyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies1178-2013https://doaj.org/article/8e651498b70a43899bab6b4ee4c85b282016-04-01T00:00:00Zhttps://www.dovepress.com/hyperthermia-mediated-by-dextran-coated-la07sr03mno3-nanoparticles-in--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Reihaneh Haghniaz, Rinku D Umrani, Kishore M Paknikar Centre for Nanobioscience, Agharkar Research Institute, Pune, India Purpose: The aim of this study was to evaluate radiofrequency-induced dextran-coated lanthanum strontium manganese oxide nanoparticles-mediated hyperthermia to be used for tumor regression in mice.Materials and methods: Nanoparticles were injected intra-tumorally in melanoma-bearing C57BL/6J mice and were subjected to radiofrequency treatment.Results: Hyperthermia treatment significantly inhibited tumor growth (~84%), increased survival (~50%), and reduced tumor proliferation in mice. Histopathological examination demonstrated immense cell death in treated tumors. DNA fragmentation, increased terminal deoxynucleotidyl transferase-dUTP nick end labeling signal, and elevated levels of caspase-3 and caspase-6 suggested apoptotic cell death. Enhanced catalase activity suggested reactive oxygen species-mediated cell death. Enhanced expression of heat shock proteins 70 and 90 in treated tumors suggested the possible development of “antitumor immunity”.Conclusion: The dextran-coated lanthanum strontium manganese oxide-mediated hyperthermia can be used for the treatment of cancer. Keywords: lanthanum strontium manganese oxide nanoparticles, melanoma, tumor regression, survival, heat shock proteins, MRIHaghniaz RUmrani RDPaknikar KMDove Medical Pressarticlehyperthermialanthanum strontium manganese oxide nanoparticlesmelanomatumor regressionsurvivalheat shock proteinsMRIMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1779-1791 (2016) |
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hyperthermia lanthanum strontium manganese oxide nanoparticles melanoma tumor regression survival heat shock proteins MRI Medicine (General) R5-920 |
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hyperthermia lanthanum strontium manganese oxide nanoparticles melanoma tumor regression survival heat shock proteins MRI Medicine (General) R5-920 Haghniaz R Umrani RD Paknikar KM Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies |
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Reihaneh Haghniaz, Rinku D Umrani, Kishore M Paknikar Centre for Nanobioscience, Agharkar Research Institute, Pune, India Purpose: The aim of this study was to evaluate radiofrequency-induced dextran-coated lanthanum strontium manganese oxide nanoparticles-mediated hyperthermia to be used for tumor regression in mice.Materials and methods: Nanoparticles were injected intra-tumorally in melanoma-bearing C57BL/6J mice and were subjected to radiofrequency treatment.Results: Hyperthermia treatment significantly inhibited tumor growth (~84%), increased survival (~50%), and reduced tumor proliferation in mice. Histopathological examination demonstrated immense cell death in treated tumors. DNA fragmentation, increased terminal deoxynucleotidyl transferase-dUTP nick end labeling signal, and elevated levels of caspase-3 and caspase-6 suggested apoptotic cell death. Enhanced catalase activity suggested reactive oxygen species-mediated cell death. Enhanced expression of heat shock proteins 70 and 90 in treated tumors suggested the possible development of “antitumor immunity”.Conclusion: The dextran-coated lanthanum strontium manganese oxide-mediated hyperthermia can be used for the treatment of cancer. Keywords: lanthanum strontium manganese oxide nanoparticles, melanoma, tumor regression, survival, heat shock proteins, MRI |
format |
article |
author |
Haghniaz R Umrani RD Paknikar KM |
author_facet |
Haghniaz R Umrani RD Paknikar KM |
author_sort |
Haghniaz R |
title |
Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies |
title_short |
Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies |
title_full |
Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies |
title_fullStr |
Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies |
title_full_unstemmed |
Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies |
title_sort |
hyperthermia mediated by dextran-coated la0.7sr0.3mno3 nanoparticles: in vivo studies |
publisher |
Dove Medical Press |
publishDate |
2016 |
url |
https://doaj.org/article/8e651498b70a43899bab6b4ee4c85b28 |
work_keys_str_mv |
AT haghniazr hyperthermiamediatedbydextrancoatedla07sr03mno3nanoparticlesinvivostudies AT umranird hyperthermiamediatedbydextrancoatedla07sr03mno3nanoparticlesinvivostudies AT paknikarkm hyperthermiamediatedbydextrancoatedla07sr03mno3nanoparticlesinvivostudies |
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1718403511634362368 |