Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

Reihaneh Haghniaz, Rinku D Umrani, Kishore M Paknikar Centre for Nanobioscience, Agharkar Research Institute, Pune, India Purpose: The aim of this study was to evaluate radiofrequency-induced dextran-coated lanthanum strontium manganese oxide nanoparticles-mediated hyperthermia to be used for tumo...

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Auteurs principaux:	Haghniaz R, Umrani RD, Paknikar KM
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2016
Sujets:	hyperthermia lanthanum strontium manganese oxide nanoparticles melanoma tumor regression survival heat shock proteins MRI Medicine (General) R5-920
Accès en ligne:	https://doaj.org/article/8e651498b70a43899bab6b4ee4c85b28
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spelling	oai:doaj.org-article:8e651498b70a43899bab6b4ee4c85b282021-12-02T00:46:37ZHyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies1178-2013https://doaj.org/article/8e651498b70a43899bab6b4ee4c85b282016-04-01T00:00:00Zhttps://www.dovepress.com/hyperthermia-mediated-by-dextran-coated-la07sr03mno3-nanoparticles-in--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Reihaneh Haghniaz, Rinku D Umrani, Kishore M Paknikar Centre for Nanobioscience, Agharkar Research Institute, Pune, India Purpose: The aim of this study was to evaluate radiofrequency-induced dextran-coated lanthanum strontium manganese oxide nanoparticles-mediated hyperthermia to be used for tumor regression in mice.Materials and methods: Nanoparticles were injected intra-tumorally in melanoma-bearing C57BL/6J mice and were subjected to radiofrequency treatment.Results: Hyperthermia treatment significantly inhibited tumor growth (~84%), increased survival (~50%), and reduced tumor proliferation in mice. Histopathological examination demonstrated immense cell death in treated tumors. DNA fragmentation, increased terminal deoxynucleotidyl transferase-dUTP nick end labeling signal, and elevated levels of caspase-3 and caspase-6 suggested apoptotic cell death. Enhanced catalase activity suggested reactive oxygen species-mediated cell death. Enhanced expression of heat shock proteins 70 and 90 in treated tumors suggested the possible development of “antitumor immunity”.Conclusion: The dextran-coated lanthanum strontium manganese oxide-mediated hyperthermia can be used for the treatment of cancer. Keywords: lanthanum strontium manganese oxide nanoparticles, melanoma, tumor regression, survival, heat shock proteins, MRIHaghniaz RUmrani RDPaknikar KMDove Medical Pressarticlehyperthermialanthanum strontium manganese oxide nanoparticlesmelanomatumor regressionsurvivalheat shock proteinsMRIMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1779-1791 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperthermia lanthanum strontium manganese oxide nanoparticles melanoma tumor regression survival heat shock proteins MRI Medicine (General) R5-920
spellingShingle	hyperthermia lanthanum strontium manganese oxide nanoparticles melanoma tumor regression survival heat shock proteins MRI Medicine (General) R5-920 Haghniaz R Umrani RD Paknikar KM Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies
description	Reihaneh Haghniaz, Rinku D Umrani, Kishore M Paknikar Centre for Nanobioscience, Agharkar Research Institute, Pune, India Purpose: The aim of this study was to evaluate radiofrequency-induced dextran-coated lanthanum strontium manganese oxide nanoparticles-mediated hyperthermia to be used for tumor regression in mice.Materials and methods: Nanoparticles were injected intra-tumorally in melanoma-bearing C57BL/6J mice and were subjected to radiofrequency treatment.Results: Hyperthermia treatment significantly inhibited tumor growth (~84%), increased survival (~50%), and reduced tumor proliferation in mice. Histopathological examination demonstrated immense cell death in treated tumors. DNA fragmentation, increased terminal deoxynucleotidyl transferase-dUTP nick end labeling signal, and elevated levels of caspase-3 and caspase-6 suggested apoptotic cell death. Enhanced catalase activity suggested reactive oxygen species-mediated cell death. Enhanced expression of heat shock proteins 70 and 90 in treated tumors suggested the possible development of “antitumor immunity”.Conclusion: The dextran-coated lanthanum strontium manganese oxide-mediated hyperthermia can be used for the treatment of cancer. Keywords: lanthanum strontium manganese oxide nanoparticles, melanoma, tumor regression, survival, heat shock proteins, MRI
format	article
author	Haghniaz R Umrani RD Paknikar KM
author_facet	Haghniaz R Umrani RD Paknikar KM
author_sort	Haghniaz R
title	Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies
title_short	Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies
title_full	Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies
title_fullStr	Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies
title_full_unstemmed	Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies
title_sort	hyperthermia mediated by dextran-coated la0.7sr0.3mno3 nanoparticles: in vivo studies
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/8e651498b70a43899bab6b4ee4c85b28
work_keys_str_mv	AT haghniazr hyperthermiamediatedbydextrancoatedla07sr03mno3nanoparticlesinvivostudies AT umranird hyperthermiamediatedbydextrancoatedla07sr03mno3nanoparticlesinvivostudies AT paknikarkm hyperthermiamediatedbydextrancoatedla07sr03mno3nanoparticlesinvivostudies
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Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

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